Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris
Figure 3
Association of clinical relapses of rituximab (Rtx)-treated pemphigus vulgaris (PV) patients and the reappearance of IgG against distinct regions of the Dsg3 ectodomain. Three of the 6 PV patients (PV3, PV6, PV23) showed an increase of IgG reactive with the Dsg3EC1 subdomain upon clinical relapse after Rtx therapy. Patient PV13 showed increased serum levels of IgG against the Dsg3EC4 subdomain while patients PV5 and PV19 did not show altered IgG levels against any of the studied Dsg3 subdomains upon clinical relapse.
