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Dermatology Research and Practice
Volume 2010, Article ID 584353, 7 pages
Review Article

Mouse Models for Blistering Skin Disorders

1Department of Dermatology, University of Colorado Medical School, 12800 East 19th Avenue, Aurora, CO 80045, USA
2Department of Cell and Developmental Biology, University of Colorado Medical School, Aurora, CO 80045, USA

Received 12 January 2010; Accepted 24 February 2010

Academic Editor: Mỹ G. Mahoney

Copyright © 2010 Radhika Ganeshan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes. This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia. A comparison of the phenotypes observed in these mouse lines is provided and the relationship between the mutant mouse phenotypes and human diseases, in particular pemphigus vulgaris, is discussed. Furthermore, we will discuss the advantages and potential limitations of genetically engineered mouse lines in our ongoing quest to understand blistering skin diseases.