Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity

Table 1

Affinity of FcγR for the IgG. Relative affinity of human and mouse Fc gamma receptors for the different isotypes of human and mouse Immunoglobulins G.

	hFcγRIIB	hFcγRIIA	hFcγRIIIA	hFcγRI
Ka	<10^7 M	<10^7 M	1-2×10^7 M	10^8-10^9 M
human IgG	3>1=4⋙2	HR 3>1⋙2,4	3>1⋙2,4	3=1>4⋙2
		LR 3>1=2⋙4
mouse IgG	2a=2b>1,3	HR 2a=2b=1	3>2a>2b⋙1	2a=3≫1,2b
		LR2a=2b⋙1
	mFcγRIIB	mFcγRIII	mFcγRIV	mFcγRI
Ka	<10^7 M	<10^7 M	3×10^7 M	10^8 M
mouse IgG	1=2b>2a⋙3	2a=2b=1⋙3	2a=2b⋙1,3	2a⋙1,2b,3
human IgG	3>1>2≫4	1=3>2≫4	1,3	3>1>4≫2