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Dermatology Research and Practice
Volume 2010, Article ID 690613, 6 pages
http://dx.doi.org/10.1155/2010/690613
Review Article

Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring

Renovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UK

Received 15 March 2010; Accepted 3 July 2010

Academic Editor: Hayes B. Gladstone

Copyright © 2010 Jim Bush et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. L. Young and J. Hutchison, “Insights into patient and clinician concerns about scarring,” Plastic and Reconstructive Surgery, vol. 124, no. 1, pp. 256–265, 2009. View at Google Scholar
  2. V. L. Young, J. Bush, and S. O'Kane, “A new approach for the prophylactic improvement of surgical scarring: avotermin (TGFβ3),” Clinics in Plastic Surgery, vol. 36, no. 2, pp. 307–313, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. W. J. Ferguson and S. O'Kane, “Scar-free healing: from embryonic mechanism to adult therapeutic intervention,” Philosophical Transactions of the Royal Society B, vol. 359, no. 1445, pp. 839–850, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Meier and L. B. Nanney, “Emerging new drugs for scar reduction,” Expert Opinion on Emerging Drugs, vol. 11, no. 1, pp. 39–47, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. T. A. Mustoe, R. D. Cooter, M. H. Gold et al., “International clinical recommendations on scar management,” Plastic and Reconstructive Surgery, vol. 110, no. 2, pp. 560–571, 2002. View at Google Scholar · View at Scopus
  6. R. G. Reish and E. Eriksson, “Scars: a review of emerging and currently available therapies,” Plastic and Reconstructive Surgery, vol. 122, no. 4, pp. 1068–1078, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. G. Reish and E. Eriksson, “Scar treatments: preclinical and clinical studies,” Journal of the American College of Surgeons, vol. 206, no. 4, pp. 719–730, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Tierney, B. H. Mahmoud, D. Srivastava, D. Ozog, and D. J. Kouba, “Treatment of surgical scars with nonablative fractional laser versus pulsed dye laser: a randomized controlled trial,” Dermatologic Surgery, vol. 35, no. 8, pp. 1172–1180, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. N. L. Occleston, S. O'Kane, N. Goldspink, and M. W. J. Ferguson, “New therapeutics for the prevention and reduction of scarring,” Drug Discovery Today, vol. 13, no. 21-22, pp. 973–981, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Durani and A. Bayat, “Levels of evidence for the treatment of keloid disease,” Journal of Plastic, Reconstructive and Aesthetic Surgery, vol. 61, no. 1, pp. 4–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. W. J. Ferguson, D. J. Whitby, M. Shah, J. Armstrong, J. W. Siebert, and M. T. Longaker, “Scar formation: the spectral nature of fetal and adult wound repair,” Plastic and Reconstructive Surgery, vol. 97, no. 4, pp. 854–860, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. R. L. McCallion and M. W. J. Ferguson, “Fetal wound healing and the development of antiscarring therapies for adult wound healing,” in The Molecular and Cellular Biology of Wound Repair, R. A. F. Clarke, Ed., pp. 561–600, Plenum Press, New York, NY, USA, 1996. View at Google Scholar
  13. S. O'Kane and M. W. J. Ferguson, “Transforming growth factor βs and wound healing,” International Journal of Biochemistry and Cell Biology, vol. 29, no. 1, pp. 63–78, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. M. E. Schrementi, A. M. Ferreira, C. Zender, and L. A. DiPietro, “Site-specific production of TGF-β in oral mucosal and cutaneous wounds,” Wound Repair and Regeneration, vol. 16, no. 1, pp. 80–86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. H. B. Chen, J. G. Rud, K. Lin, and L. Xu, “Nuclear targeting of transforming growth factor-β-activated Smad complexes,” Journal of Biological Chemistry, vol. 280, no. 22, pp. 21329–21336, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Y. Lin, K. M. Sullivan, P. A. Argenta, M. Meuli, H. P. Lorenz, and N. S. Adzick, “Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair,” Annals of Surgery, vol. 222, no. 2, pp. 146–154, 1995. View at Google Scholar · View at Scopus
  17. M. Shah, D. M. Foreman, and M. W. J. Ferguson, “Control of scarring in adult wounds by neutralising antibody to transforming growth factor β,” The Lancet, vol. 339, no. 8787, pp. 213–214, 1992. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Shah, D. M. Foreman, and M. W. J. Ferguson, “Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring,” Journal of Cell Science, vol. 108, no. 3, pp. 985–1002, 1995. View at Google Scholar · View at Scopus
  19. N. L. Occleston, H. G. Laverty, S. O'Kane, and M. W. J. Ferguson, “Prevention and reduction of scarring in the skin by transforming growth factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical,” Journal of Biomaterials Science, vol. 19, no. 8, pp. 1047–1063, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Durani, N. Occleston, S. O'Kane, and M. W. J. Ferguson, “Avotermin: a novel antiscarring agent,” International Journal of Lower Extremity Wounds, vol. 7, no. 3, pp. 160–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Laverty, N Occleston, R. Jones et al., “Effects of transforming growth factor beta 3 in a clinically relevant model of full thickness incisional wounding in the Gottingen minipig,” Wound Repair Regen. In press.
  22. J. S. Bond, J. A. L. Duncan, A. Sattar et al., “Maturation of the human scar: an observational study,” Plastic and Reconstructive Surgery, vol. 121, no. 2, pp. 487–496, 2008. View at Google Scholar
  23. J. S. Bond, J. A. L. Duncan, T. Mason et al., “Scar redness in humans: how long does it persist after incisional and excisional wounding?” Plastic and Reconstructive Surgery, vol. 121, no. 2, pp. 487–496, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. A. L. Duncan, J. S. Bond, T. Mason et al., “Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality?” Plastic and Reconstructive Surgery, vol. 118, no. 4, pp. 909–918, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. M. W. J. Ferguson, J. Duncan, J. Bond et al., “Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies,” The Lancet, vol. 373, no. 9671, pp. 1264–1274, 2009. View at Publisher · View at Google Scholar · View at Scopus