A Hypothesis Concerning a Potential Involvement of Ceramide in Apoptosis and Acantholysis Induced by Pemphigus Autoantibodies

<table>Sphingomyelin synthase. The reaction catalyzed by sphingomyelin synthase (SM synthase) results in a reduction in ceramide and an increase in diacylglycerol and sphingomyelin levels.  The reported phosphatidylcholine-specific phospholipase C inhibitor D609 also inhibits sphingomyelin synthase activity.</table>

Dermatology Research and Practice

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Figure 2

Figure 2: A Hypothesis Concerning a Potential Involvement of Ceramide in Apoptosis and Acantholysis Induced by Pemphigus Autoantibodies 