Dermatology Research and Practice / 2010 / Article / Tab 5

Clinical Study

The Sensitivity and Specificity of Potassium Hydroxide Smear and Fungal Culture Relative to Clinical Assessment in the Evaluation of Tinea Pedis: A Pooled Analysis

Table 5

Sensitivity, specificity, and predictive value for KOH smear and culture with clinical cure at six weeks as gold standard overall and for component studies (a–f).
(a) Overall ( ).

Clinical Cure
YesNo

CultureNeg7861
Pos109212
Total187273
SENSITIVITY (%) 41.7
SPECIFICITY (%)77.7 (72.2–82.5)
PV Neg 56.1 (47.4–64.5)
PV Pos (%)66.0 (60.6–71.2)

Neg137157
KOH SmearPos50116
Total187273
SENSITIVITY (%)73.3 (66.3–79.5)
SPECIFICITY (%)42.5 (36.6–48.6)
PV Neg (%)46.6 (40.8–52.5)
PV Pos (%)69.9 (62.3–76.7)

= Predictive value, ,
with exact 95% binomial confidence limits.
(b) Study STUDY #1 ( ).

Clinical Cure
YesNo

CultureNeg189
Pos2845
Total4654
SENSITIVITY (%)39.1 (25.1–54.6)
SPECIFICITY (%)83.3 (70.7–92.1)
PV Neg (%)66.7 (46.0–83.5)
PV Pos (%)61.6 (49.5–72.8)

KOH SmearNeg4240
Pos414
Total4654
SENSITIVITY (%)91.3 (79.2–97.6)
SPECIFICITY (%)25.9 (15.0–39.7)
PV Neg (%)51.2 (39.9–62.4)
PV Pos (%)77.8 (52.4–93.6)

(c) Study STUDY #2 ( ).

Clinical Cure
YesNo

CultureNeg1912
Pos2232
Total4144
SENSITIVITY (%)46.3 (30.7–62.6)
SPECIFICITY (%)72.7 (57.2–85.0)
PV Neg (%)61.3 (42.2–78.2)
PV Pos (%)59.3 (45.0–72.4)
Neg2935
KOH SmearPos129
Total4144
SENSITIVITY (%)70.7 (54.5–83.9)
SPECIFICITY (%)20.5 (9.8–35.3)
PV Neg (%)45.3 (32.8–58.3)
PV Pos (%)42.9 (21.8–66.0)

(d) Study STUDY #3 ( ).

Clinical Cure
YesNo

CultureNeg811
Pos1052
Total1863
SENSITIVITY (%)44.4 (21.5–69.2)
SPECIFICITY (%)82.5 (70.9–90.9)
PV Neg (%)42.1 (20.3–66.5)
PV Pos (%)83.9 (72.3–92.0)

KOH SmearNeg1535
Pos328
Total1863
SENSITIVITY (%)83.3 (58.6–96.4)
SPECIFICITY (%)44.4 (31.9–57.5)
PV Neg (%)30.0 (17.9–44.6)
PV Pos (%)90.3 (74.2–98.0)

(e) Study STUDY #4 ( ).

Clinical Cure
YesNo

CultureNeg1513
Pos2232
Total3745
SENSITIVITY (%)40.5 (24.8–57.9)
SPECIFICITY (%)71.1 (55.7–83.6)
PV Neg (%)53.6 (33.9–72.5)
PV Pos (%)59.3 (45.0–72.4)

KOH SmearNeg2526
Pos1219
Total3745
SENSITIVITY (%)67.6 (50.2–82.0)
SPECIFICITY (%)42.2 (27.7–57.9)
PV Neg (%)49.0 (34.8–63.4)
PV Pos (%)61.3 (42.2–78.2)

(f) Study STUDY #5 ( ).

Clinical Cure
YesNo

CultureNeg1816
Pos2851
Total4667
SENSITIVITY (%)39.1 (25.1–54.6)
SPECIFICITY (%)76.1 (64.1–85.7)
PV Neg (%)52.9 (35.1–70.2)
PV Pos (%)64.6 (53.0–75.0)

KOH SmearNeg2721
Pos1946
Total4667
SENSITIVITY (%)58.7 (43.2–73.0)
SPECIFICITY (%)68.7 (56.2–79.4)
PV Neg (%)56.3 (41.2–70.5)
PV Pos (%)70.8 (58.2–81.4)

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