Table 1: Characteristic differences observed between fetal and adult wound healing.

Fetal Wound HealingAdult Wound Healing

InflammationMinimalRobust

Select Growth Factors
PDGFTransientSustained
FGFLowHigh
TGFβLow TGFβ1 and TGFβ2High TGFβ1 and TGFβ2
High TGFβ3Low TGFβ3

Proinflammatory cytokines
IL-6LowHigh
IL-8LowHigh

Anti-inflammatory cytokine
IL-10
HighLow

Formation of granulation tissueNoYes

ECM Proteins
CollagenIncreased Type III collagen
(ratio of type III : type I is high)
Increased Type I collagen
(ratio of type I : type III is high)
FibronectinEarly DepositionLate Deposition
TenascinEarly AppearanceLate Appearance

Proteoglycans and Glycosaminoglycans
Hyaluronic AcidHighLow
FibromodulinHighLow
DecorinLowHigh

MyofibroblastsNoYes

Integrins during re-epithelializationEarlyLate

CCT-subunits
CCT-etaLowHigh
CCT-betaNo changeNo change