Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing

Table 2

Observed differences between fetal and adult fibroblasts.

	Fetal Fibroblast	Adult Fibroblast
alpha-SMA; (serum containing cultures)	Low	High
In-vitro collagen; contraction	Less	More
Hyaluronic acid; (HA)	Increased HA synthesis; irrespective of cell density	Decreased HA synthesis; as cell density increases
Hyaluronic acid; receptor	High	Low
Proinflammatory; cytokines
IL-6	Low	High
IL-8	Low	High
CCT-subunits
CCT-eta	Low	High
CCT-beta	No change	No change