A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma
Changes in MASI scores and colorimetric values for 4% HQ and 4% niacinamide-treated sides in 27 patients with melasma. Mast cell counts and melanin expression initially and after treatment with niacinamide in 11 patients.
|MASI score was calculated for each treated half-face. |
No statistical differences were found in redness (a*) for both treatments, before and after.
Final depigmentation Improvement (L*) did not show differences between both treatments (). In parenthesis, confidence Interval to 95%.