Table of Contents Author Guidelines Submit a Manuscript
Dermatology Research and Practice
Volume 2012 (2012), Article ID 198789, 18 pages
Review Article

The Infant Skin Barrier: Can We Preserve, Protect, and Enhance the Barrier?

1JOHNSON & JOHNSON Consumer Companies, Inc., 199 Grandview Road, Skillman, NJ 08558, USA
2Evidence Scientific Solutions, 123 South Broad Street, Suite 1670, Philadelphia, PA 19109, USA
3JOHNSON & JOHNSON Santé Beauté France, 1 rue Camille Desmoulins, 92787 Issy-les-Moulineaux, France

Received 20 April 2012; Accepted 15 June 2012

Academic Editor: Alex Zvulunov

Copyright © 2012 Lorena S. Telofski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infant skin is different from adult in structure, function, and composition. Despite these differences, the skin barrier is competent at birth in healthy, full-term neonates. The primary focus of this paper is on the developing skin barrier in healthy, full-term neonates and infants. Additionally, a brief discussion of the properties of the skin barrier in premature neonates and infants with abnormal skin conditions (i.e., atopic dermatitis and eczema) is included. As infant skin continues to mature through the first years of life, it is important that skin care products (e.g., cleansers and emollients) are formulated appropriately. Ideally, products that are used on infants should not interfere with skin surface pH or perturb the skin barrier. For cleansers, this can be achieved by choosing the right type of surfactant, by blending surfactants, or by blending hydrophobically-modified polymers (HMPs) with surfactants to increase product mildness. Similarly, choosing the right type of oil for emollients is important. Unlike some vegetable oils, mineral oil is more stable and is not subject to oxidation and hydrolysis. Although emollients can improve the skin barrier, more studies are needed to determine the potential long-term benefits of using emollients on healthy, full-term neonates and infants.