A Synopsis of Serum Biomarkers in Cutaneous Melanoma Patients

Figure 1

The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. Sentinel lymph node is the first draining lymph node in which melanoma cells may find a suitable environment and survive, leading to micro- or macrometastasis. If the cells spread hematogenously, distant metastasis will appear.