miRNAs and Melanoma: How Are They Connected?

Table 1

Alterations of miRNAs machinery biogenesis components and their role on tumorigenesis.

Altered components	Cell type	Consequence	Reference
Dgcr8 knockout	mouse stem cells	miRNA synthesis disruption, cell proliferation and differentiation changes	[29]
Drosha increase	squamous cells carcinoma	miRNA profile modification	[30]
XPO5 mutation	in a subset of human tumors	pre-miRNA accumulation	[27]
Dicer increase	cutaneous malignant melanomas	—	[38]
TRBP2 mutation	colorectal and endometrial cancer cells	DICER1 destabilization and miRNA processing disturbed	[42]
Ago2 increase	breast cancer cells	more aggressive phenotype of breast cancer lineage negative for ER expression	[47]