Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use
Table 4
Local tolerability assessments.
Evaluator-assessed erythema, dryness, and peeling
Grade
Severity
Erythema
Dryness
Peeling
0
Absent
No redness
None
No peeling
1
Slight
Faint red or pink coloration, barely perceptible
Barely perceptible dryness with no flakes or fissure formation
Mild localized peeling
2
Mild
Light red or pink coloration
Easily perceptible dryness with no flakes or fissure formation
Mild and diffuse peeling
3
Moderate
Medium red coloration
Easily noted dryness and flakes but no fissure formation
Moderate and diffuse peeling
4
Severe
Beet red coloration
Easily noted dryness with flakes and fissure formation