Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation

Table 4

(a) Results of analysis of variances (ANOVAs) for every fatty acid from C12:0 to C18:2n6c+C18:2n6t, based on group treatment and visit. (b) Results of analysis of variances (ANOVAs) for every fatty acid from C18:3n6 to C24:0 (with squalene and total identified fatty acids), based on group treatment and visit.

(a)  

Fatty acid	Factor	Degrees of freedom of numerator	Degrees of freedom of denominator	𝐹-test	𝑃 value
C12:0	Group	2	37	3.578	0.038
	Visit	3	111	3.688	0.014
	Group ∗ Visit	6	111	1.361	0.237
C13:0	Group	2	37	0.524	0.597
	Visit	2	86	0.851	0.445
	Group ∗ Visit	5	86	1.525	0.195
C14:0	Group	2	37	0.422	0.659
	Visit	3	98	3.235	0.031
	Group ∗ Visit	5	98	0.358	0.885
C14:1	Group	2	37	0.155	0.857
	Visit	2	86	0.154	0.885
	Group ∗ Visit	5	86	0.745	0.582
C15:0	Group	2	37	0.033	0.967
	Visit	2	91	3.516	0.025
	Group ∗ Visit	5	91	0.375	0.862
C15:1	Group	2	37	1.406	0.258
	Visit	1	40	1.161	0.292
	Group ∗ Visit	2	40	1.103	0.345
C16:0	Group	2	37	2.270	0.117
	Visit	3	96	1.947	0.136
	Group ∗ Visit	5	96	0.284	0.926
C16:1	Group	2	37	0.290	0.750
	Visit	3	93	7.596	<0.001
	Group ∗ Visit	5	93	0.535	0.749
C17:0	Group	2	37	0.127	0.881
	Visit	3	102	1.599	0.198
	Group ∗ Visit	6	102	0.416	0.853
C17:1	Group	2	37	0.264	0.769
	Visit	3	102	0.634	0.581
	Group ∗ Visit	6	102	1.098	0.371
C18:0	Group	2	37	3.113	0.056
	Visit	3	105	2.905	0.041
	Group ∗ Visit	6	105	0.578	0.739
C18:1n9c+C18:1n9t	Group	2	37	4.612	0.016
	Visit	3	111	0.439	0.725
	Group ∗ Visit	6	111	0.284	0.944
C18:2n6c	Group	2	37	0.799	0.457
	Visit	3	111	2.004	0.118
	Group ∗ Visit	6	111	0.553	0.767
C18:2n6t	Group	2	37	0.147	0.864
	Visit	1	42	5.401	0.021
	Group ∗ Visit	2	42	0.328	0.749
C18:2n6c+C18:2n6t	Group	2	37	0.197	0.822
	Visit	2	70	2.229	0.118
	Group ∗ Visit	4	70	0.569	0.677

(b)  

Fatty acid	Factor	Degrees of freedom of numerator	Degrees of freedom of denominator	𝐹-test	𝑃 value
C18:3n6	Group	2	37	0.377	0.689
	Visit	2	76	4.945	0.009
	Group * Visit	4	76	0.985	0.423
C18:3n3	Group	2	37	0.626	0.541
	Visit	2	67	5.118	0.011
	Group * Visit	4	67	0.634	0.625
C20:0	Group	2	37	0.178	0.838
	Visit	2	68	2.121	0.132
	Group * Visit	4	68	0.159	0.949
C20:1	Group	2	37	0.923	0.406
	Visit	1	40	5.392	0.023
	Group * Visit	2	40	1.099	0.347
C20:2	Group	2	37	0.925	0.406
	Visit	1	39	0.899	0.354
	Group * Visit	2	39	0.925	0.410
C21:0	Group	2	37	1.299	0.285
	Visit	2	67	0.334	0.697
	Group * Visit	4	67	0.402	0.789
C20:3n3	Group	2	37	0.029	0.971
	Visit	1	43	2.905	0.090
	Group * Visit	2	43	0.1	0.929
C20:5n3	Group	2	37	2.133	0.133
	Visit	1	41	2.168	0.147
	Group * Visit	2	41	2.550	0.085
C22:0	Group	2	37	0.535	0.590
	Visit	1	40	4.796	0.032
	Group * Visit	2	40	0.431	0.653
C22:1n9	Group	2	37	1.177	0.319
	Visit	2	79	0.322	0.739
	Group * Visit	4	79	1.145	0.343
C22:2	Group	2	37	1.002	0.377
	Visit	1	39	3.802	0.056
	Group * Visit	2	39	1.002	0.380
C23:0	Group	2	37	1.177	0.319
	Visit	1	39	1.239	0.275
	Group * Visit	2	39	1.177	0.321
C24:0	Group	2	37	0.254	0.777
	Visit	3	111	2.821	0.042
	Group * Visit	6	111	1.595	0.155
Squalene	Group	2	37	1.252	0.298
	Visit	3	99	1.761	0.165
	Group * Visit	5	99	0.704	0.631
Total identified	Group	2	37	1.548	0.226
	Visit	3	101	1.087	0.354
	Group * Visit	5	101	0.241	0.953