Dermatology Research and Practice / 2013 / Article / Tab 3

Clinical Study

In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology

Table 3

Reflectance confocal microscopy, high-definition optical coherence tomography, and conventional histology morphological characteristics in lip mucosa according to tissue depth.

Reference markDepthRCM characteristicsHD-OCT “en-face” characteristicsHistology

Z00  mHighly scattering homogenousHighly scattering homogenous layer Nonhomogenously parakeratinized
Z14.96  mCytoplasmic granular appearanceGranular appearance and high scatteringWanting granular layer. Cells appear very eosinophilic, thin and flat. Narrow intercellular spaces
Z229.79  mCytoplasmic border becomes apparent Cytoplasmic granular appearance and areas with honeycomb patternCells and nuclei become flat and irregularly shaped. Nuclei acquire pyknotic appearance
Z384.36  mWider honeycomb pattern. May be difficult to clearly distinguish nuclei. Dermal papillae may start becoming visible Dermal papillae may start becoming visible In the prickle layer, cells appear round or polygonal. Nuclei seem intensely basophilic and centrally located
Z4124.00  mLoss of honeycomb pattern. Nuclei become dark and are not clearly distinguishedDermal papillaeBasal cell layer cells have a cuboidal shape containing large rounded nuclei. Mitotic activity can be easily distinguished
Z5173.00  mEpithelial junction, ill-defined papillae and collagen fibersTransitional epithelium
Z6193.69  mCollagen fibersCollagen fibersLoose connective tissue with a rich vascular supply. The deeper layers contain heavy bundles of collagen fibers

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