Clinical Study

In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology

Table 5

Mean measurements of cellular and morphologic features in lower lip mucosa in vivo by reflectance confocal microscopy and high-definition optical coherence tomography.

StructureHistology image ( m)RCM image ( m)HD-OCT image ( m)

Epithelium thickness ( m)100–245153–194 151–232
Interpapillary space33–203.7NA57.4–498
Papillae diameter (shortest/longest) ( m)99/265NA150/287.1
Capillary diameter (longest/shortest) ( m)200/34208/33261.9/36.7
Collagen fiber bundlesRegularly dispossessed reticular patternRegularly dispossessed reticular patternRegularly dispossessed reticular pattern