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Dermatology Research and Practice
Volume 2013, Article ID 379725, 10 pages
Clinical Study

The Effect of Q-Switched Nd:YAG 1064 nm/532 nm Laser in the Treatment of Onychomycosis In Vivo

1Dermatology and Laser Clinic, 88 Tsimiski Street, 54622 Thessaloniki, Greece
2Dermatology and Laser Center, Reduitstrare 13, 76829 Landau, Germany
3Gazi University Medical Faculty, Department of Dermatology, 06510 Ankara, Turkey
4Aristotle University School of Medicine, Second Department of Dermatology and Venereology, 54622 Thessaloniki, Greece
5Université Libre de Bruxelles, Department CHU Brugmann-Saint Pierre, 1050 Brussels, Belgium
6Carol Davila University of Medicine, Dionisie Lupu Street, 020021 Bucharest, Romania
7Osnabrueck University, Sedanstraße 115, 49090 Osnabrueck, Germany
8Bern University, Department of Dermatology, 117 Inselspital, 3010 Bern, Switzerland

Received 30 August 2013; Accepted 21 October 2013

Academic Editor: Craig G. Burkhart

Copyright © 2013 Kostas Kalokasidis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this prospective clinical study, the Q-Switched Nd:YAG 1064 nm/532 nm laser (Light Age, Inc., Somerset, NJ, USA) was used on 131 onychomycosis subjects (94 females, 37 males; ages 18 to 68 years). Mycotic cultures were taken and fungus types were detected. The laser protocol included two sessions with a one-month interval. Treatment duration was approximately 15 minutes per session and patients were observed over a 3-month time period. Laser fluencies of 14 J/cm2 were applied at 9 billionths of a second pulse duration and at 5 Hz frequency. Follow-up was performed at 3 months with mycological cultures. Before and after digital photographs were taken. Adverse effects were recorded and all participants completed “self-evaluation questionnaires” rating their level of satisfaction. All subjects were well satisfied with the treatments, there were no noticeable side effects, and no significant differences were found treating men versus women. At the 3-month follow-up 95.42% of the patients were laboratory mycologically cured of fungal infection. This clinical study demonstrates that fungal nail infections can be effectively and safely treated with Q-Switched Nd:YAG 1064 nm/532 nm laser. It can also be combined with systemic oral antifungals providing more limited treatment time.