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Dermatology Research and Practice
Volume 2014, Article ID 175693, 6 pages
Research Article

Metabolic Changes and Serum Ghrelin Level in Patients with Psoriasis

1Department of Dermatology, Faculty of Medicine, Dicle University, 21070 Diyarbakir, Turkey
2Department of Dermatology, Faculty of Medicine, Firat University, Elazig, Turkey
3Department of Dermatology, Elazig Training and Research Hospital, Elazig, Turkey
4Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey

Received 22 July 2014; Revised 2 December 2014; Accepted 8 December 2014; Published 18 December 2014

Academic Editor: Kiyofumi Yamanishi

Copyright © 2014 Haydar Ucak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Serum ghrelin levels may be related to metabolic and clinical changes in patients with psoriasis. Objective. This study was performed to determine the possible effects of serum ghrelin in patients with psoriasis. Methods. The study population consisted of 25 patients with plaque psoriasis. The patients were questioned with regard to age, gender, age of onset, duration of disease, height, weight, and body mass index (BMI). In addition, fasting blood sugar, triglyceride, cholesterol levels, insulin, and ghrelin levels were measured. Results. The mean serum ghrelin level was 45.41 ± 22.41 in the psoriasis group and 29.92 ± 14.65 in the healthy control group. Serum ghrelin level was significantly higher in the psoriasis group compared with the controls (). The mean ghrelin level in patients with a lower PASI score was significantly higher than in those with a higher PASI score (). Conclusion. The present study was performed to determine the effects of ghrelin in psoriasis patients. We found a negative correlation between severity of psoriasis and ghrelin level. Larger and especially experimental studies focusing on correlation of immune system-ghrelin levels and severity of psoriasis may be valuable to clarify the etiopathogenesis of the disease.