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Dermatology Research and Practice
Volume 2014, Article ID 705402, 5 pages
Clinical Study

Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis

1Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran
2Department of Preventive and Community Medicine, Guilan University of Medical Sciences, Rasht, Iran

Received 21 October 2013; Revised 11 December 2013; Accepted 4 January 2014; Published 18 February 2014

Academic Editor: Luigi Naldi

Copyright © 2014 Narges Alizadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis. Systemic antifungal therapy is another alternative in treatment. Aim. This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis. Methods. 64 patients with moderate to severe seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study. One study group took terbinafine 250 mg daily ( ) and the other one fluconazole 300 mg ( ) weekly for four weeks. Seborrheic dermatitis area severity index (SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment. Results. Both drugs significantly reduced the severity of seborrheic dermatitis ( ). Multivariate linear regression revealed that efficacy of terbinafine is more than fluconazole ( , 95% CI (0.63–4.7)). Moreover, each index of SD severity reduced 0.9 times after treatment. ( , 95% CI (0.8–1.02)). The itching rate significantly diminished ( ); however, there was no difference between these two drugs statistically. Conclusions. Both systemic antifungal therapies may reduce the severity index of SD. However, terbinafine showed more reduction in the intensity of the disease. In other words, the more the primary intensity of the disease is, the more its reduction will be. This trial is resgistered with 201102205871N1.