|
| Disease | Route of administration | Efficacy | Reference number |
|
| Warts | Topical | Efficacious as 5%, 10% zinc sulphate lotion, 20% zinc oxide paste, and 2% intralesional zinc sulphate injection. | [6, 7, 11] |
| Oral | 10 mg/kg/day oral zinc sulphate for 2 months was an effective modality for recalcitrant warts. | [9, 10] |
|
| Cutaneous leishmaniasis | Intralesional | Clinical cure with 2% intralesional zinc sulphate was comparable to meglumine antimoniate. | [12] |
| Oral | Oral zinc sulphate in doses of 2.5, 5, and 10 mg/kg/day for 45 days was an effective and safe treatment option. | [13] |
|
| Leprosy | Oral | Rapid clinical improvement in leprosy lesions and erythema nodosum leprosum seen on addition of oral zinc along with MDT. | [15, 16] |
|
| Herpes genitalis | Topical | Topical 1%, 2%, and 4% zinc sulphate for 3 months was effective in treating and preventing recurrences of herpes genitalis. | [18] |
|
| Dermatophytoses | Topical | 20% zinc-undecylenate powder applied twice daily for 4 weeks showed clinical improvement in tinea pedis. | [19] |
|
| Bromhidrosis | Topical | Topical 15% zinc sulphate solution was efficacious in management of bromhidrosis and foot malodour. | [20, 21] |
|
| Pityriasis versicolor | Topical | Topical 15% zinc sulphate solution applied once daily for 3 weeks was effective in pityriasis versicolor. | [22] |
|
| Acne vulgaris | Topical | Topical 5% zinc sulphate was effective in mild to moderate acne. | [34, 36] |
| Oral | Oral zinc sulphate and zinc gluconate were useful in moderate to severe acne. | [37–40] |
|
| Rosacea | Oral | Oral zinc sulphate 100 mg thrice a day was effective in rosacea after 3 months of therapy. | [48] |
|
| Hidradenitis suppurativa | Oral | Oral zinc gluconate 90 mg/day showed significant clinical improvement. | [50] |
|
| Psoriasis and psoriatic arthritis | Topical | Topical 0.25% zinc pyrithione applied twice daily was found useful in plaque psoriasis. | [52] |
| Oral | Oral zinc sulphate was efficacious in psoriatic arthritis. | [53] |
|
| Eczemas | Topical | Zinc oxide paste and zinc sulphate were effective in diaper dermatitis and hand eczemas. | [57] |
|
| Ulcers | Topical | Topical zinc oxide paste induced rapid healing of vascular and leprosy ulcers. | [60–62] |
| Oral | No role of systemic zinc sulphate noted in leg ulcers. | [59] |
|
| Behcet’s disease and oral aphthae | Oral | Oral zinc sulphate 100 mg/day was an effective in oral aphthosis and Behcet’s disease. | [63, 64] |
|
| Alopecia areata | Oral | 5 mg/kg/day of oral zinc sulphate induced significant hair growth after 6 months of therapy. | [68] |
|
| Oral lichen planus | Topical | 0.2% zinc mouthwash with fluocinolone was effective in oral lichen planus. | [72] |
|
| Xeroderma pigmentosum | Topical | 20% zinc sulphate solution applied twice daily cleared the solar keratoses and small malignancies. | [73] |
|
| Actinic keratoses | Topical | 25% zinc sulphate solution applied twice daily for 12 weeks cleared majority of the lesions. | [74] |
|
| Basal cell carcinoma | Intralesional | Intralesional 2% zinc gluconate was efficacious in basal cell carcinoma. | [75] |
|
| Vitiligo | Oral | Oral zinc sulphate showed moderate efficacy when given as an adjuvant with topical steroids. | [78] |
|
| Melasma | Topical | 10% zinc sulphate solution applied twice daily for 3 months showed significant reduction in MASI score. | [79] |
|
| Keloids | Topical | Locally applied zinc tape showed significant clearing and reduction in relapses of keloids. | [82, 83] |
|
| Antiageing | Topical | 0.1% copper-zinc malonate cream applied twice daily for 8 weeks showed significant reduction of wrinkles. | [84] |
|
