Table 1: Effect of type I Interferon on normal keratinocytes and melanocytes.

Type of effectDescription of effectReferences

AntiproliferativeIFNs- inhibit the growth of human keratinocytes in vitro and promote keratinocyte terminal differentiation.
IFNs- inhibit the growth of human melanocytes in vitro, with IFN- having a greater effect than IFN- .
[1720]

AntiangiogenesisIFN sensitivity of surrounding tissue is necessary for inhibition of angiogenesis around gelfoam sponges implanted in mice.[21, 22]

ImmunomodulatoryIFN- upregulates class I, but not class II, MHC antigen expression in cultured human keratinocytes.
IFNs- induce increased expression of class I MHC antigens in cultured human melanocytes, with IFN- having a greater effect than IFN- .
[20, 23]