Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies
Effect of type I Interferon on normal keratinocytes and melanocytes.
Type of effect
Description of effect
IFNs- inhibit the growth of human keratinocytes in vitro and promote keratinocyte terminal differentiation. IFNs- inhibit the growth of human melanocytes in vitro, with IFN- having a greater effect than IFN-.
IFN- upregulates class I, but not class II, MHC antigen expression in cultured human keratinocytes. IFNs- induce increased expression of class I MHC antigens in cultured human melanocytes, with IFN- having a greater effect than IFN-.