Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection

Table 1

Clinical and laboratory criteria of HCV infected patients with cutaneous manifestations ().

Variable	Value in study participants
Age range in years, mean (SD)	24–63, 47.1 (7.5)
Sex, M (%)/F (%)	84 (71.2%)/34 (28.8%)
Liver function test range, mean (SD)
AST (IU/L)	12–168, 62.6 (32.4)
ALT (IU/L)	10–177, 61 (30.5)
ALP (IU/L)	51–266, 109.6 (34.6)
Serum albumin (g/dL)	3.5–4.8, 4.1 (0.4)
Total serum bilirubin (mg/dL)	0.5–6.4, 1 (0.9)
Prothrombin time	11–18, 13.2 (1)
Skin manifestations of chronic HCV (%), +ve/−ve cryoglobulins
Pruritus	74 (62.7%), 2/72
Vasculitic lesions	9 (7.6%), 4/5
Lichen planus (oral ± cutaneous)	8 (6.8%), 1/7
Lichen planus (cutaneous only)	3 (2.5%), 0/3
Melasma	6 (5.1%), 0/6
Urticaria	4 (3.4%), 1/3
Livedo reticularis	3 (2.5%), 3/0
Necrolytic acral erythema	3 (2.5%), 0/3
Erythema nodosum	2 (1.7%), 0/2
Prurigo nodularis	2 (1.7%), 0/2
Vitiligo	2 (1.7%), 0/2
Pigmented purpuric dermatosis (Schamberg’s disease)	1 (0.8%), 1/0
Psoriasis	1 (0.8%), 0/1

ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase.