Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection

Table 2

Relationship between cryoglobulin-positivity and patients’ characteristics.

Characteristic	Cryoglobulin-positive patients ( = 12)	Cryoglobulin-negative patients ( = 106)	value (Student’s test or )
Age range in years, mean (SD)	29–63, 49.1 (7.1)	24–59, 47.4 (5.1)	0.24
Gender, (%)
Male ( = 84)	9 (75%)	75 (70.8%)	0.76
Female ( = 34)	3 (25%)	31 (29.3%)
Liver function test range, mean (SD)
AST (IU/L)	28–77, 44.9 (10.6)	12–168, 65.5 (14.6)	0.1
ALT (IU/L)	31–73, 42.9 (16.5)	10–177, 63.9 (31.3)	0.1
ALP (IU/L)	92–266, 131 (37.1)	51–200, 96.3 (5.2)	0.1
Serum albumin (g/dL)	3.6–3.9, 4 (0.5)	3.5–4.8, 4.1 (0.6)	0.7
Total serum bilirubin (mg/dL)	0.47–1.36, 1.1 (0.7)	0.5–6.4, 1 (0.9)	0.1
Prothrombin time	11–15.6, 13.2 (0.6)	11–18, 13.3 (1)	0.6
Cutaneous extrahepatic manifestations associated with MC, (%)			value; ()	Odds ratio (95% confidence)
Pruritus ( = 74)	2 (16.6%)	72 (67.9%)	0.001	0.09 (0.02–0.5)
Vasculitic lesions of lower limbs ( = 9)	4 (33.3%)	5 (4.7%)	<0.001	10.1 (2.3–45.2)
Oral lichen planus ( = 8)	1 (8.3%)	7 (6.6%)	0.82	1.29 (0.1–11.4)
Chronic urticaria ( = 4)	1 (8.3%)	3 (2.8%)	0.32	3.12 (0.3–32.6)
Livedo reticularis ( = 3)	3 (25%)	0	<0.001	—
Pigmented purpuric dermatosis ( = 1)	1 (8.3%)	0	0.003	—

MC: mixed cryoglobulinemia; significant.