Research Article
Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection
Table 2
Relationship between cryoglobulin-positivity and patients’ characteristics.
| Characteristic | Cryoglobulin-positive patients ( = 12) | Cryoglobulin-negative patients ( = 106) | value (Student’s test or ) |
| Age range in years, mean (SD) | 29–63, 49.1 (7.1) | 24–59, 47.4 (5.1) | 0.24 | Gender, (%) | | | | | Male ( = 84) | 9 (75%) | 75 (70.8%) | 0.76 | Female ( = 34) | 3 (25%) | 31 (29.3%) | | | Liver function test range, mean (SD) | | | | | AST (IU/L) | 28–77, 44.9 (10.6) | 12–168, 65.5 (14.6) | 0.1 | ALT (IU/L) | 31–73, 42.9 (16.5) | 10–177, 63.9 (31.3) | 0.1 | ALP (IU/L) | 92–266, 131 (37.1) | 51–200, 96.3 (5.2) | 0.1 | Serum albumin (g/dL) | 3.6–3.9, 4 (0.5) | 3.5–4.8, 4.1 (0.6) | 0.7 | Total serum bilirubin (mg/dL) | 0.47–1.36, 1.1 (0.7) | 0.5–6.4, 1 (0.9) | 0.1 | Prothrombin time | 11–15.6, 13.2 (0.6) | 11–18, 13.3 (1) | 0.6 |
| Cutaneous extrahepatic manifestations associated with MC, (%) | | | value () | Odds ratio (95% confidence) |
| Pruritus ( = 74) | 2 (16.6%) | 72 (67.9%) | 0.001 | 0.09 (0.02–0.5) | Vasculitic lesions of lower limbs ( = 9) | 4 (33.3%) | 5 (4.7%) | <0.001 | 10.1 (2.3–45.2) | Oral lichen planus ( = 8) | 1 (8.3%) | 7 (6.6%) | 0.82 | 1.29 (0.1–11.4) | Chronic urticaria ( = 4) | 1 (8.3%) | 3 (2.8%) | 0.32 | 3.12 (0.3–32.6) | Livedo reticularis ( = 3) | 3 (25%) | 0 | <0.001 | — | Pigmented purpuric dermatosis ( = 1) | 1 (8.3%) | 0 | 0.003 | — |
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MC: mixed cryoglobulinemia; significant.
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