Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse

Figure 2

(a) Histology of healing wound tissue by hematoxylin and eosin stain at the indicated time intervals in dorsal skin of inducible nitric oxide synthase (iNOS-) knockout (KO) mice and WT mice. (b) The thickness of the granulation tissue at the center zone was thinner in KO mice than in WT mice at days 6 and 8 with a statistically significant difference. (c) At the margin zone, the thickness of the granulation tissue was significantly thinner in KO mice than in WT mice at day 6. Open bars: WT, filled bars: KO (days 3, 11, and 14: ; days 6, 8: animals in each group). Mean ± standard deviation. ; ; bar, 1 mm.

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