Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse

Figure 6

Expression of mRNA of α-smooth muscle actin (αSMA), F4/80, transforming growth factor β1 (TGFβ1), and collagen 1α2 in normal skin of wild type (WT) and inducible nitric oxide synthase (iNOS-) knockout (KO) mice. (a–c) Expression of αSMA, F4/80 and TGFβ1 mRNA was significantly more marked in KO normal skin compared with WT tissues. (d) Expression level of collagen 1α2 mRNA was more prominent in KO normal skin, but there was no significant difference between WT and KO. Open bars: WT, filled bars: KO. Mean ± standard deviation. ; n.s., not significant.

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