Table of Contents Author Guidelines Submit a Manuscript
Dermatology Research and Practice
Volume 2017, Article ID 3518568, 11 pages
https://doi.org/10.1155/2017/3518568
Review Article

Clinical and Genetic Review of Hereditary Acral Reticulate Pigmentary Disorders

Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence should be addressed to H. Alshaikh; moc.liamg@hkiahslala.mahseh

Received 6 June 2017; Accepted 17 September 2017; Published 23 October 2017

Academic Editor: E. Helen Kemp

Copyright © 2017 H. Alshaikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired disorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content. This review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica hereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura. The clinical presentation and histopathological features often overlap, making diagnosis difficult. However, each of these hereditary conditions possesses a unique genetic mutation, and genetic analysis is thus more useful in the diagnosis of these conditions. This article delivers an update regarding the clinical features, detailed histopathological description, and genetic information concerning hereditary reticulate pigmentary disorders and aims to provide useful background for use by clinical dermatologists and histopathologists when approaching this group of hereditary disorders.