Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study

Table 1

Patient data.

Number	Age (years)	Gender	Type of EB	Collagen VII staining; (IFM)	Mutation; cDNA	Mutation protein	Skin involvement
1	6	M	RDEB; (SG)	Negative	c.3141delG; homozygous	p.Cys1048; 61	Generalized blistering, scarring, mutilations
2	10	F	RDEB; (SG)	Not done	c.4590delA; homozygous	p.Gly1531; 179	Generalized blistering, scarring, mutilations
3	16	F	RDEB; (SG)	Not done	c.4590delA; homozygous	p.Gly1531; 179	Generalized blistering, scarring, mutilations
4	9	M	RDEB; (SG)	Not done	c.1934delC; homozygous	p.Pro645; 45	Generalized blistering, scarring, ++pseudo synechiae
5	36	M	RDEB; (SG)	Negative	425A>G; homozygous	p.?; Altered splicing	Generalized blistering, scarring, mutilations
6	47	F	RDEB; (GI)	Reduced	c.3832-2A>G; 4039G>T	p.?; G1347W	Generalized blistering, scarring, mild proximal pseudo synechiae
7	21	M	DDEB; (loc.)	Normal	c.7868G>T	p.Gly2623Val	Blistering on lower legs, nail dystrophy
8	28	M	RDEB; (SG)	Not done	Not done	Not done	Generalized blistering, scarring, mutilations
9	20	M	RDEB; (SG)	Not done	c.2212_2215dup; 7621C>T	p.Glu739; GlyfsX2	Generalized blistering, scarring, mutilations
10	17	M	RDEB; (SG)	Negative	c.[425A>G]; 1837C>T	p.?; Arg613X	Generalized blistering, scarring, mutilations

EB: epidermolysis bullosa; DDEB: dominant dystrophic EB; RDEB: recessive dystrophic EB; SG: severe generalized; GI: generalized intermediate; loc.: localized; IFM: immunofluorescence mapping.