Probiotics in the Management of Atopic Dermatitis for Children: A Case-Based Review

Table 2

Validity appraisal of RCTs based on CEBM critical appraisal tools.

Author	No. of participants	Level of evidence	Validity^a
			Randomization	Baseline similarity	Equally treated	Intention to treat	Blinding
Navarro-Lopez et al. [15]	50	2	+	+	+	+	+
Prakoeswa et al. [16]	22	2	?	+	+	+	?
Yang et al. [17]	70^b	2	+	+	+	−	+
Woo et al. [18]	88	2	?	+	+	−	+
Han et al. [19]	108	2	+	+	+	+	+

^aValidity demonstrated by: +, clearly stated; −, not done; ?, not clearly stated. ^bOut of 100 initial participants, only 70 participants finished the study. The conclusion was made based on the per-protocol analysis.