Children, 0–14-year-old with atopic dermatitis who met the Hanifin–Rajka diagnostic criteria, age-related total serum IgE levels of 10–15 years > 200 IU/mL, 6–9 years > 90 IU/mL, 1–5 years > 60 IU/mL, <1 year > 1.5 IU/mL
L. plantarum IS-10506 at the dose of 1010 cfu/day for 12 weeks in microencapsulated form
SCORAD index
A statistically significant decrease of SCORAD score in the probiotic group was observed (); however, MCID was not achieved (SCORAD < 8.7)
Children, 2–9-year-old with mild to moderate atopic dermatitis (SCORAD score ≤40) who met the Hanifin–Rajka diagnostic criteria without any chronic underlying disease, acute GI infection, or past exposure to commercial probiotics/systemic corticosteroid/antibiotic/immunosuppressive agent/Chinese herbal therapies 4 weeks prior to enrollment
Mixture of L. casei, L. rhamnosus, L. plantarum, and B. lactis in glucose anhydrous crystalline powder derived from corn starch; a single dose preparation containing 1 × 109 cfu of each bacterial strain, given for 6 weeks, twice daily
EASI (eczema area and severity index) and VASP (visual analog scale for pruritus) scores
Statistically significant decrease in EASI and VASP scores before and after treatment in both probiotic and control groups
No statistically significant difference between probiotic and control groups in EASI and VASP scores at week 6
Children, 2–10-year-old with moderate and severe AEDS (atopic eczema dermatitis syndrome)
Microcrystalline cellulose (1.76 g) as a carrier of freeze-dried L. sakei KCTC 10755BP; a dose of 5 × 109 cfu of L. sakei was given twice daily
SCORAD index
SCORAD total score-adjusted pretreatment values were lower after probiotic vs placebo treatment at week 12 (); there was a greater improvement in mean disease activity with probiotic (31%) vs. placebo use (13%), ; however, MCID was not achieved
Children, 1–13-year-old presenting with AD with SCORAD ranged from 20–50
L. plantarum CJLP133 at the dose of 0.5 × 1010 given twice daily for 12 weeks
SCORAD index
Mean change of the SCORAD score from baseline in probiotic group was greater than in placebo group, both in ITT () and PP analysis (); however, MCID was not passed