Systemic Glutathione as a Skin-Whitening Agent in Adult

Table 2

Summary of critical appraisal of included RCTs.

Author	Validity							Relevance
	Study design	Subject size	Randomization	Intention to treat	Blinding	Equal treatment	Similar baseline characteristics	Domain	Determinant	Outcome measurements	Level of evidence
Arjinpathana and Asawanonda (2010) [1]	RCT	60	+	+	+	+	+	+	+	+	2
Zubair et al. (2016) [4]	RCT	32	—	—	—	+	+	+	+	+	2
Weschawalit et al. (2017) [3]	RCT	60	+	+	+	+	+	+	+	+	2