Microneedling in Combination with Topical Pimecrolimus 1% versus Topical Pimecrolimus 1% for the Treatment of Refractory Stable Vitiligo: A Randomized Clinical Trial

Table 2

Comparison between topical pimecrolimus therapy and combination therapy according to degree of repigmentation during the treatment and follow-up period.

Treatment method	Pimecrolimus	Combination of microneedling and pimecrolimus				Fischer’s exact test
Repigmentation status	Poor	Poor	Fair	Good	Excellent
After 2 weeks	15 (100%)	15 (100%)	0 (0%)	0 (0%)	0 (0%)	—
After 1 month	15 (100%)	14 (93.3%)	1 (6.7%)	0 (0%)	0 (0%)	0.999
After 45 days	15 (100%)	11 (73.3%)	4 (26.7%)	0 (0%)	0 (0%)	0.027
After 2 months	15 (100%)	9 (60%)	6 (40%)	0 (0%)	0 (0%)	0.01
After 75 days	15 (100%)	6 (40%)	7 (46.7%)	2 (13.3%)	0 (0%)	0.001
After 3 months	15 (100%)	6 (40%)	4 (26.7%)	5 (33.3%)	0 (0%)	<0.001
After 6 months’ follow-up	15 (100%)	6 (40%)	4 (26.7%)	4 (26.7%)	1 (6.7%)	<0.001
Friedman test	—	<0.001