The Efficacy of Lactocare® Synbiotic on the Clinical Symptoms in Patients with Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Akbarzadeh, Ali; Alirezaei, Pedram; Doosti-Irani, Amin; Mehrpooya, Maryam; Nouri, Fatemeh

doi:https://doi.org/10.1155/2022/4549134

Dermatology Research and Practice

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Abstract Introduction Methods Results Discussion Conclusion Data Availability Additional Points Ethical Approval Conflicts of Interest Authors’ Contributions Acknowledgments Supplementary Materials References Copyright Related Articles

Research Article | Open Access

Volume 2022 | Article ID 4549134 | https://doi.org/10.1155/2022/4549134

The Efficacy of Lactocare® Synbiotic on the Clinical Symptoms in Patients with Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ali Akbarzadeh,¹Pedram Alirezaei,²Amin Doosti-Irani,³Maryam Mehrpooya,⁴and Fatemeh Nouri¹

Academic Editor: Craig G. Burkhart

Received03 Jul 2022

Accepted27 Sept 2022

Published07 Oct 2022

Abstract

Background. Attention to the administration of probiotics for the treatment of psoriasis has recently increased. Aim. In the present study, improvements in dermatology life quality index (DLQI), psoriasis area severity index (PASI), and visual analogue scale (VAS) scores in the psoriasis patients receiving Lactocare® probiotic were compared to psoriasis patients receiving placebo. Methods. A total of 52 psoriasis patients were included in this study and randomly divided into treatment and placebo (control) groups. The control group received topical hydrocortisone associated with placebo; in the treatment group, Lactocare® was administrated orally associated with hydrocortisone. The mean of VAS, DLQI, and PSAI scores was recorded and evaluated pretreatment and post-treatment in both groups for 3 months. The mean of the scores in the control groups was compared to the treatment group. Intragroup analysis was preformed with a comparison of the mean of these scores at baseline 4-, 8-, and 12-weeks post-treatment. Results. In the treatment group, a significant decrease was seen in PASI, VAS, and DLQI scores compared to the control group on week 12 post-treatment. Conclusion. Oral administration of Lactocare® probiotic (two times daily) associated with administration of topical hydrocortisone resulted in the improvement of PASI, DLQI, and VAS scores in the patients with psoriasis after 12 weeks of treatment. PASI reduction occurred in all patients who received probiotics.

1. Introduction

Psoriasis is a chronic, inflammatory, and immune-mediated disease characterized by the development of scaly, sharply demarcated erythematous, pruritic, indurated, and often painful skin plaques [1]. It is estimated that more than 125 million (0.09–11.4%) people suffer from psoriasis in the world. Psoriasis not only is considered to be a dermatological disease but has also recently been defined as a systemic one due to the multiple organs’ involvement with an important impact on social, psychological, and economic life [2]. Although the pathogenesis of psoriasis has not yet been completely known, the interaction between innate and adaptive immune systems is known as the underlying pathomechanisms of psoriasis [3]. In addition, genetic background, ethnicity, and environmental factors have been shown to affect the onset of the disease [3, 4]. The inflammatory cytokines, such as interleukin IL-12, IL-17, IL-23, and tumor necrosis factor TNF-α are elevated in the peripheral blood of patients with psoriasis [5].

Topical and systemic immunosuppressants (systemic corticosteroids), cyclosporine or methotrexate, and phototherapy are used for the treatment of psoriasis [6]. Anti-TNF-α, anti-IL-23, and IL-17, and monoclonal antibodies have been recently developed for the treatment of the disease [7, 8]. Despite the fact that monoclonal antibodies are more effective than topical or systemic immunosuppressants, they are associated with high economic costs and adverse effects [9]. Clinicians have recently been attempting to develop better treatment options for skin illnesses such as psoriasis, and probiotic therapy is gaining popularity [10]. In this regard, some studies have been conducted on integrative remedies for skin diseases such as topical cream of the Malva sylvestris extract [11], oral supplementation of whey protein [12], and other natural compound [13] formulations that significantly improve the severity of inflammatory skin diseases. Probiotics are live exogenous nonpathogenic microorganisms that confer a health benefit for atopic dermatitis, psoriasis, and acne when they are administered in sufficient quantities [14, 15]. Probiotics have been reported to protect the host from infections resulting from the immunomodulatory effect, increasing the production of immunoglobulins, and activation of immune cells such as mononuclear cells and lymphocytes [16]. Probiotics have been hypothesized to have a beneficial role in the treatment of psoriasis. Since the anti-inflammatory effect of a brand of preprobiotics named Lactocare® on the disease severity of ulcerative colitis patients [17] and also on the serum electrolytes and trace elements in psoriatic patients [18] has previously been reported, this study aimed to evaluate the effect of Lactocare® on the treatment of psoriasis using the psoriasis area severity index (PASI), Visual Analogue Scale (VAS), and dermatology life quality index (DLQI).

2. Material and Methods

2.1. Subject and Study Design

In this case-control double-blind clinical trial study (this study is registered by the Iranian Registry of Clinical Trials with the code: IRCT20120215009014N323) that was conducted during 2020–2021, and the required sample size with a standard deviation of 1.5 units, the first type of error of 5%, and the test power of 80% were considered in two groups of 32 people.

2.2. Intervention and Ethics

After providing the written informed agreement, 52 individuals with psoriasis were enrolled in this study (27 and 25 patients in the placebo and therapy groups, respectively) (12 people lost owing to the COVID-19 pandemic, and the study was discontinued). The Ethics Committee of Hamadan University of Medical Sciences, Hamadan, Iran, also approved the study protocol (ethical approval number: IR. UMSHA. REC. 1398.725).

2.3. Outcomes and Measures

The inclusion criteria were a clinical diagnosis of psoriasis confirmed by a dermatologist, aged between 18 and 60 years and a lack of history of consumption of probiotics and drugs 1 to 6 weeks before the beginning of the experiment, PASI ≥2%. Diabetic and immunosuppressant patients and patients with a history of immunosuppressing drug consumption were excluded from the study. The severity of the disease was measured using the PASI score. In brief, the body was classified into four regions including the head, trunk, and upper and lower extremities. To calculate the PASI score, the doctor graded the psoriasis plaques found on each body region for their combined redness, thickness, and scaliness (A scores). The severity of the plaques in each region is graded on a 0 to 4 scale, with 0 meaning no involvement and 4 meaning severe involvement. Next, he calculated the amount of the surface area on each body region that is covered by plaques (B scores). The total surface area affected by psoriasis is graded from 0 to 6, with 0 meaning no involvement and 6 meaning greater than 90 percent of the region covered in plaques. Then, he multiplied the A score by B score for each body region to get four C scores. Then, he multiplied each C score by the amount of the body surface area that the region represents. This amount is 0.1 for the head and neck, 0.2 for the arms, 0.3 for the trunk, and 0.4 for the legs.

DLQI is a self-reported questionnaire that consists of 10 questions to evaluate the effect of psoriasis on the quality of life of patients with psoriasis [19]. This 4-point scale (0 = not at all to 3 = very much) questionnaire was divided into six commonly identified categories. The highest possible DLQI score was 30, and the higher scores indicate a higher effect on the quality of life [20]. The patients with psoriasis were asked to report their itch VAS score during the last 24 h on a VAS score ranging from “no itch at all” to “worst (maximal intensity) itch you can imagine. The patients were randomly divided into two groups including the control and treatment groups via block randomization. The control group received weak corticosteroid (hydrocortisone) topically associated with placebo for three months. In the treatment group, Lactocare® purchased from Zist Takhmir Company, (two times daily) was administrated orally associated with weak corticosteroid or hydrocortisone for three months. VAS, DLQI, and PSAI scores were evaluated pre-treatment and post-treatment. The mean of the scores in the control groups was compared to the treatment group.

2.4. Statistical Analysis

Data were analyzed using SPSS version 22, and the data were expressed as the mean ± standard error of the mean (SEM). The mean of the scores in both groups was compared using an independent t-test. Intragroup analysis was conducted using repeated-measure ANOVA. The chi-squared test was used to compare the demographic data, and one-way ANOVA was used to compare the mean scores in various age groups. was considered a statistical difference.

3. Results

3.1. Demographical Findings

A total of 52 patients (33 male and 19 female) completed the study. The male-to-female ratio was 1.73 in the psoriasis patients. Demographical data including sex, duration of disease, and age are shown in Table 1. There was no significant difference between the control and treatment groups in sex (). There was no significant difference between the treatment and control groups in terms of the mean duration time of () (Table 1).

3.2. PASI, VAS, and DLQI Findings on Placebo Compared to Treatment

The comparison of the baseline, weeks 4, 8, and 12, PASI, VAS, and DLQI scores in both groups was performed to determine the effectiveness of treatment. The results are shown in Table 2. There was no significant difference between the treatment and placebo groups in terms of the baseline PASI score as well as the PASI score of weeks 4 and 8 post-treatment (). However, in the treatment group, a significant decrease was seen in the PASI score compared to the control group on week 12 post-treatment (4.08 ± 0.28 vs 6.19 ± 0.39, ) (Supplementary 1).

There was no significant difference between the treatment and placebo groups in terms of the baseline VAS score as well as the VAS score of weeks 4 and 8 post-treatment (). However, in the treatment group, a significant decrease was seen in the VAS score compared to the control group on week 12 post-treatment (32.24 ± 4.29 vs 48.11 ± 4.88, ) (Supplementary 2). There was no significant difference between the treatment and placebo groups in terms of the baseline DLQI score as well as the DLQI score of weeks 4 and 8 post-treatment (). However, in the treatment group, a significant decrease was seen in the DLQI score compared to the control group on week 12 post-treatment (6.56 ± 0.63 vs 8.92 ± 0.71, ) (Supplementary 3).

The PASI, VAS, and DLQI scores at the baseline and at weeks 4, 8, and 12 were compared to assess treatment efficacy during the study, and the results are shown in Table 3. In the treatment group, the intragroup analysis showed that the mean PASI, VAS, and DLQI scores were significantly lower at weeks 4, 8, and 12 post-treatment than that at baseline. In addition, the PASI score was significantly lower at week 12 than those of weeks 8 and 4 post-treatment as well as at week 8 than that of 4 weeks post-treatment ().

For evaluation of the efficacy of placebo during the study, the PASI, VAS, and DLQI scores in each group at the baseline and at weeks 4, 8, and 12 were compared, and the obtained data are shown in Table 4. In the control group, the intragroup analysis showed that no significant difference was seen between all post-treatment interval times with each other as well as the baseline in terms of PASI, VAS, and DLQI scores ().

3.3. PASI, VAS, and DLQI Score Findings Based on Age and Sex

Regardless of the treatment, the patients were classified into 4 age groups: 20 to 30 (10 cases, 19.2%), 31 to 40 (17 cases, 32.7%), 41 to 50 (14 cases, 26.9%), and up to 51 (11 cases, 21.2%) years old. The PASI, VAS, and DLQI scores of various ages are shown in Table 5. There was no significant difference between both groups in terms of various age classifications. The frequency of age 20 to 30, 31 to 40, 41 to 50, and up to 51 years old were 20.0% (5 cases), 16.0% (4 cases), 36.0% (9 cases), and 28.0% (7 cases) in the treatment group as well as 18.5% (5 cases), 48.1% (13 cases), 18.5% (5 cases), and 14.8% (4 cases) for the control group, respectively. Regardless, the gender and the mean PASI, VAS, and DLQI scores in various ages of the treatment group are shown in Table 5. There was no significant difference respected in the mean of PASI, VAS, and DLQI scores in various age groups in the treatment group.

There was no significant difference between male and female patients in terms of PASI, VAS, and DLQI baseline and all interval times post-treatment in the treatment group as well as the control group (Supplementary 4.). At the 12-week follow-up, two of the patients (7.41%) in the control group and all patients (100%) in the treatment group showed a reduction in PASI.

4. Discussion

Attention to the administration of probiotics for the treatment of psoriasis has recently increased. In the present study, improvement in DLQI, PASI, and VAS scores in the psoriasis patients receiving Lactocare® probiotics was compared to psoriasis patients receiving a placebo. In addition, the effect of age and sex on the efficacy of treatment on the improvement of these scores was evaluated. Multiple metrics such as PASI, DLQI, and VAS have been introduced to evaluate the efficacy of psoriasis treatment [21]. Currently, it has been demonstrated that the PASI, which combines the extent of the afflicted area and the assessment of the severity of lesions in a single index score, is the gold standard for determining therapy efficacy in patients with moderate-to-severe psoriasis [22]. The improvement of all three psoriasis indexes in the probiotic group at week 12 post-treatment compared to the placebo group was the main finding of the current study. On the other hand, at the 12-week follow-up, 100% of the patients in the treatment group and 7.41% of the patients in the control group both showed a reduction in PASI. These findings show that the effect of simultaneous administration of hydrocortisone with oral administration of probiotics on the improvement of psoriasis indexes is achieved 12 weeks after treatment. The improvement of the psoriasis index in the probiotic group may attribute to the anti-inflammatory effect and intestinal microbial composition of Lactocare®. There is no study conducted on these probiotics as a treatment in patients with psoriasis.

The inflammatory cytokines, such as TNF-α, IL-12, IL-23, and IL-17, are increased in the peripheral blood of psoriasis patients [5]. Phototherapy and topical or systemic immunosuppressants and anticytokine therapies are associated with a high economic cost and, rarely, they may activate latent infectious diseases [7, 8]. The elevated Th17 cells are notorious in the intestine and skin that are reported to relate to the pathogenesis of inflammatory diseases such as psoriasis. Th17 cells and their counterpart regulatory T cells are balanced by the intestinal microbiome [23]. Probiotics are nonpathogenic microorganisms with several potential mechanisms including adjustment of the intestinal microbiota composition, growth, function, and increasing local immune responses [24, 25]. The intestinal microbiota is the intestinal normal flora of the human body that plays an important role in human health, especially in the regulation of metabolic events and the development of the host immune system [24]. Lactocare®, a preprobiotic (synbiotic), has been used in this study that has been reported to treat mild-to-moderate ulcerative colitis due to its anti-inflammatory properties [17]. Despite the fact that exact pathogenesis of psoriasis is unknown, it is mostly believed that abnormal activation of immune cell functions plays an important role in the onset of the disease. Since psoriasis is an immune-mediated inflammatory disease, the control or stimulation of inflammatory response can improve or develop and progress disease [26].

Efficacy and safety of oral administration of probiotic strains and lower risk of relapse after the intake of the probiotic mixture in patients with psoriasis and modulation of the microbiota composition after 12 weeks have been recently reported by Navarro-López et al. [16]. IL-10, a type 2 cytokine, has been reported to have numerous immunosuppressive and anti-inflammatory properties. It has also inhibited antigen-presenting cells (APCs) including macrophages, dendritic cells, and monocytes [27–29]. Experimentally, administration of IL-10 resulted in shift-type 1 cytokines to type 2 cytokines. In addition, the treatment effect of ultraviolet light on the modulation of inflammation by up-regulation of the IL-10 in keratinocytes has been previously shown [30]. On the other hand, decreasing the level of IL-10 has been demonstrated to consider a critical way to induce disease flare-ups in the psoriatic skin [31].

In this study, the mean of PASI, DLQI, and VAS scores in the treatment group was also compared to the placebo group based on age and sex. According to these criteria, we have found no significant difference between male and female patients in the treatment group and the placebo group. Hägg et al. by measuring PASI in psoriasis patients reported that the severity of psoriasis differs between men and women [32]. This discrepancy can contribute to the number of patients and sample size or lifestyle such as smoking status and disease duration. However, the male-to-female ratio in our study was 1.73 indicating that men are more infected with psoriasis.

The obtained data from the intragroup analysis showed that the mean PASI, VAS, and DLQI scores were significantly decreased following spent time and treatment compared to the baseline in the treatment group, not the placebo. The highest decreasing PASI, VAS, and DLQI scores were detected 12 weeks after treatment followed by weeks 8 and 4. These findings show that the efficacy of the administration of probiotics in decreasing these scores can detect 4 weeks after treatment. In the present study, the age of 31 to 40 years old was reported as the highest frequency of age for having been infected with psoriasis. Middle-aged patients have been reported to show higher rates of severe nail psoriasis [33] which is in disagreement with our findings that may be due to the classification of age and sample size and the kind of disease in which they have only studied nail psoriasis.

5. Conclusion

In conclusion, PASI, DLQI, and VAS scores are improved in the psoriasis patients who were orally administered Lactocare® probiotic (two times daily) associated with topical administration of hydrocortisone 12 weeks after treatment. PASI reduction occurred in all patients who received probiotics. Oral administration of Lactocare® also could improve the psoriasis indexes 4 weeks after treatment. However, the disease was mostly detected in males, and the age between 31 and 40 years old was identified as the highest frequency age for infection.

5.1. Study Limitation

Since the study was conducted at the time of the COVID-19 pandemic, the lack of cooperation of all patients and the exclusion of some of them from the study was the main limitation of the present study.

Data Availability

All data are available via the corresponding author.

Additional Points

Impact of Findings on Practice Statements. (i) Probiotics are important in keeping the body healthy. (ii) Oral administration of probiotics improves symptoms in patients with psoriasis.

Ethical Approval

This study has been approved by the Ethics Committee of Hamadan University of Medical Sciences. Hamadan, Iran (this study is registered by the Iranian Registry of Clinical Trials with the code: IRCT20120215009014N323 and ethics approval code: IR. UMSHA. REC. 1398.725).

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Authors’ Contributions

The conception and design of the study were carried out by F. N and A. A; acquisition of data, analysis, and interpretation of data were conducted by A. A, F. N, P. A, and M. M; drafting of the article was conducted by A. A and F. N; revision of the article critically for important intellectual content was performed by A. A, P. A, M. M, A. D, and F. N; final approval of the version to be submitted was given by F. N.

Acknowledgments

The authors are thankful to Hamadan University of Medical Sciences, Hamadan, Iran, for financial support. The authors thank Zist Takhmir Company for their assistance in Lactocare® supply. The authors would like to declare that the current research is a part of Mr. Ali Akbarzadeh’s doctorate dissertation, funded by Hamadan University of Medical Sciences, Hamadan, Iran (Grant no. 9811158775).

Supplementary Materials

Supplementary. 1: the mean PASI score in the treatment (A) and placebo (B) groups at the baseline (0), weeks 4 (1), 8 (2), and 12 (3) post-treatment. Supplementary. 2: the mean VAS score in the treatment (A) and placebo (B) groups at the baseline (0), weeks 4 (1), 8 (2), and 12 (3) post-treatment. Supplementary. 3: the mean DLQI score in the treatment (A) and placebo (B) groups at the baseline (0), weeks 4 (1), 8 (2), and 12 (3) post-treatment. Supplementary 4: comparison of PASI, VAS, and DLQI scores at the baseline and week 12 post-treatment in female and male patients in both groups. (Supplementary Materials)

References

N. Korman, “Management of psoriasis as a systemic disease: what is the evidence?” British Journal of Dermatology, vol. 182, no. 4, pp. 840–848, 2020.
View at: Publisher Site | Google Scholar
F. Russo, M. Vispi, R. Sirna et al., “Tuscan consensus on the use of UVBnb phototherapy in the treatment of psoriasis. Giornale italiano di dermatologia e venereologia: organo ufficiale,” Societa Italiana Di Dermatologia E Sifilografia, vol. 154, no. 2, pp. 99–105, 2018.
View at: Google Scholar
K. Kamiya, M. Kishimoto, J. Sugai, M. Komine, and M. Ohtsuki, “Risk factors for the development of psoriasis,” International Journal of Molecular Sciences, vol. 20, no. 18, p. 4347, 2019.
View at: Publisher Site | Google Scholar
G. S. Sagoo, R. Tazi-Ahnini, J. W. Barker et al., “Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28–q31 in Caucasian and Chinese Hans population,” Journal of Investigative Dermatology, vol. 122, no. 6, pp. 1401–1405, 2004.
View at: Publisher Site | Google Scholar
M. Pirowska, K. Podolec, S. Lipko-Godlewska et al., “Level of inflammatory cytokines tumour necrosis factor α, interleukins 12, 23 and 17 in patients with psoriasis in the context of metabolic syndrome,” Advances in Dermatology and Allergology, vol. 36, no. 1, pp. 70–75, 2019.
View at: Publisher Site | Google Scholar
E. Sbidian, A. Chaimani, S. Afach et al., “Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis,” Cochrane Database of Systematic Reviews, vol. 12, no. 12, Article ID CD011535, 2017.
View at: Publisher Site | Google Scholar
A. Wasilewska, M. Winiarska, M. Olszewska, and L. Rudnicka, “Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases,” Advances in Dermatology and Allergology, vol. 4, no. 4, pp. 247–252, 2016.
View at: Publisher Site | Google Scholar
L. Mallbris, P. Larsson, S. Bergqvist, E. Vingard, F. Granath, and M. Stahle, “Psoriasis phenotype at disease onset: clinical characterization of 400 adult cases,” Journal of Investigative Dermatology, vol. 124, no. 3, pp. 499–504, 2005.
View at: Publisher Site | Google Scholar
P. I. F. Chun and H. Lehman, “Current and future monoclonal antibodies in the treatment of atopic dermatitis,” Clinical Reviews in Allergy and Immunology, vol. 59, no. 2, pp. 208–219, 2020.
View at: Publisher Site | Google Scholar
Y. Deng, Z. Fang, S. Cui et al., “Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro,” Journal of Functional Foods, vol. 81, Article ID 104433, 2021.
View at: Publisher Site | Google Scholar
M. Meysami, M. H. Hashempur, M. Kamalinejad, and M. Emtiazy, “Efficacy of short term topical malva sylvestris l. cream in pediatric patients with atopic dermatitis: a randomized double-blind placebocontrolled clinical trial. endocrine,” Metabolic & Immune Disorders Drug Targets, vol. 21, no. 9, pp. 1673–1678, 2020.
View at: Publisher Site | Google Scholar
S. Alyasin, S. H. Nabavizadeh, H. Esmaeilzadeh et al., “Efficacy of oral supplementation of whey protein in patients with contact dermatitis: a pilot randomized double-blind placebo-controlled clinical trial,” Dermatologic Therapy, vol. 33, no. 6, Article ID e14260, 2020.
View at: Publisher Site | Google Scholar
A. Pourang, A. J. Hendricks, and V. Y. Shi, “Managing dermatology patients who prefer all natural treatments,” Clinics in Dermatology, vol. 38, no. 3, pp. 348–353, 2020.
View at: Publisher Site | Google Scholar
C. Hill, F. Guarner, G. Reid et al., “Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic,” Nature Reviews Gastroenterology & Hepatology, vol. 11, no. 8, pp. 506–514, 2014.
View at: Publisher Site | Google Scholar
B. De Pessemier, L. Grine, M. Debaere, A. Maes, B. Paetzold, and C. Callewaert, “Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions,” Microorganisms, vol. 9, no. 2, p. 353, 2021.
View at: Publisher Site | Google Scholar
V. Navarro-López, A. Martinez-Andres, A. Ramirez-Bosca et al., “Efficacy and safety of oral administration of a mixture of probiotic strains in patients with psoriasis: a randomized controlled clinical trial,” Acta Dermato-Venereologica, vol. 99, no. 12, pp. 1078–1084, 2019.
View at: Publisher Site | Google Scholar
T. Amiriani, N. Rajabli, M. Faghani et al., “Effect of Lactocare® synbiotic on disease severity in ulcerative colitis: a randomized placebo-controlled double-blind clinical trial,” Middle East journal of digestive diseases, vol. 12, no. 1, pp. 27–33, 2019.
View at: Publisher Site | Google Scholar
A. Akbarzadeh, M. Taheri, B. Ebrahimi et al., “Evaluation of lactocare® synbiotic administration on the serum electrolytes and trace elements levels in psoriasis patients: a randomized, double-blind, placebo-controlled clinical trial study,” Biological Trace Element Research, vol. 200, no. 10, pp. 4230–4237, 2022.
View at: Google Scholar
P. A. Barot, B. Nirmal, V. N. Hemlata, K. Darshan, and S. Malhotra, “Quality of life in patients with psoriasis at a tertiary care teaching hospital–A cross sectional study,” National Journal of Medical Research, vol. 5, pp. 93–97, 2015.
View at: Google Scholar
V. Shankar, S. Ghosh, K. Ghosh, and U. Chaudhuri, “PASI and PQOL-12 score in psoriasis: is there any correlation?” Indian Journal of Dermatology, vol. 56, no. 3, p. 287, 2011.
View at: Publisher Site | Google Scholar
P. Mattei, K. Corey, and A. Kimball, “Psoriasis area severity index (PASI) and the dermatology life quality index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies,” Journal of the European Academy of Dermatology and Venereology, vol. 28, no. 3, pp. 333–337, 2014.
View at: Publisher Site | Google Scholar
L. Puig, H. Thom, P. Mollon, H. Tian, and G. Ramakrishna, “Clear or almost clear skin improves the quality of life in patients with moderate-to-severe psoriasis: a systematic review and meta-analysis,” Journal of the European Academy of Dermatology and Venereology, vol. 31, no. 2, pp. 213–220, 2017.
View at: Publisher Site | Google Scholar
A. J. van Beelen, M. B. Teunissen, M. L. Kapsenberg, and E. C. de Jong, “Interleukin-17 in inflammatory skin disorders,” Current Opinion in Allergy and Clinical Immunology, vol. 7, no. 5, pp. 374–381, 2007.
View at: Publisher Site | Google Scholar
L. A. Derikx, L. A. Dieleman, and F. Hoentjen, “Probiotics and prebiotics in ulcerative colitis,” Best Practice & Research Clinical Gastroenterology, vol. 30, no. 1, pp. 55–71, 2016.
View at: Publisher Site | Google Scholar
M. M. Meyer, K. A. Fries-Craft, and E. A. Bobeck, “Composition and inclusion of probiotics in broiler diets alter intestinal permeability and spleen immune cell profiles without negatively affecting performance1,” Journal of Animal Science, vol. 98, no. 1, p. skz383, 2020.
View at: Publisher Site | Google Scholar
B. Y. Yang, Y. G. Cheng, L. Datura Metel et al., “Datura metel L. ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production through TLR7/8–MyD88–NF-κb–NLRP3 inflammasome pathway,” Molecules, vol. 24, no. 11, p. 2157, 2019.
View at: Publisher Site | Google Scholar
O. Ernst, Y. Glucksam-Galnoy, B. Bhatta et al., “Exclusive temporal stimulation of IL-10 expression in LPS-stimulated mouse macrophages by cAMP inducers and type I interferons,” Frontiers in Immunology, vol. 10, p. 1788, 2019.
View at: Publisher Site | Google Scholar
S. H. von Lanzenauer, K. Wolk, C. Hoflich et al., “Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10’s inhibitory mechanisms,” Genes and Immunity, vol. 16, no. 1, pp. 8–14, 2015.
View at: Publisher Site | Google Scholar
R. S. Mitra, T. A. Judge, F. O. Nestle, L. A. Turka, and B. J. Nickoloff, “Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression,” Journal of Immunology, vol. 154, no. 6, pp. 2668–2677, 1995.
View at: Google Scholar
A. Farid, A. Tawfik, B. Elsioufy, and G. Safwat, “Narrow band ultraviolet B therapy deactivates Th1/Th17 pathway and activates Th2 cytokines secretion in egyptian psoriatic arthritis patients,” Journal of Radiation Research and Applied Sciences, vol. 13, no. 1, pp. 356–361, 2020.
View at: Publisher Site | Google Scholar
K. Asadullah, R. Sabat, M. Friedrich, H. Volk, and W. Sterry, “Interleukin-10: an important immunoregulatory cytokine with major impact on psoriasis,” Current Drug Targets - Inflammation & Allergy, vol. 3, no. 2, pp. 185–192, 2004.
View at: Publisher Site | Google Scholar
D. Hägg, A. Sundstrom, M. Eriksson, and M. Schmitt-Egenolf, “Severity of psoriasis differs between men and women: a study of the clinical outcome measure psoriasis area and severity index (PASI) in 5438 swedish register patients,” American Journal of Clinical Dermatology, vol. 18, no. 4, pp. 583–590, 2017.
View at: Publisher Site | Google Scholar
A. Trettel, C. Spehr, A. Korber, and M. Augustin, “The impact of age on psoriasis health care in Germany,” Journal of the European Academy of Dermatology and Venereology, vol. 31, no. 5, pp. 870–875, 2017.
View at: Publisher Site | Google Scholar

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Copyright © 2022 Ali Akbarzadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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