Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity
Table 3
Relation between CD70 and CD27 gene expression in AA lesions and signs of AA activity (positive hair pull test and dermoscopic features) (n = 40).
N
CD 70 in AA lesion
Test of sig.
p
CD27 in AA lesion
Test of sig.
P
Mean ± SD
Median
IQR (25th–75th)
Mean ± SD
Median
IQR (25th–75th)
Black dots
Absent
10
0.69 ± 0.59
0.57
1.01 (0.18–1.07)
U = 48.0
0.001
0.45 ± 0.41
0.21
0.78 (0.12–0.85)
U = 24.0
<0.001
Present
30
2.98 ± 2.90
1.89
3.56 (1.04–4.59)
4.10 ± 3.79
2.0
6.22 (1.25–7.46)
Broken hair
Absent
24
1.65 ± 2.86
1.04
1.28 (0.21–1.44)
U = 68.0
<0.001
1.71 ± 2.56
1.01
1.71 (0.37–1.91)
U = 68.0
<0.001
Present
16
3.55 ± 2.07
3.65
4.02 (1.58–5.11)
5.40 ± 3.98
4.94
7.57 (1.93–8.62)
Tapering hair
Absent
14
0.81 ± 0.64
0.95
0.93 (0.21–1.07)
U = 69.0
0.001
0.60 ± 0.45
0.63
0.91 (0.12–1.03)
U = 36.0
<0.001
Present
26
3.27 ± 3.01
2.04
3.76 (1.09–4.59)
4.58 ± 3.85
2.53
6.33 (1.82–7.46)
Positive hair pull test
Absent
18
0.82 ± 0.65
0.95
1.13 (0.20–1.33)
U = 55.0
<0.001
0.58 ± 0.45
0.63
0.89 (0.12–0.99)
U = 0.0
<0.001
Present
22
3.71 ± 3.06
2.89
4.51 (1.11–5.62)
5.32 ± 3.74
4.50
7.71 (2.0–9.71)
SD: standard deviation; IQR: interquartile range. U : Mann–Whitney test. ∗Significant at p value less than 0.05. AA: alopecia areata; CD: cluster differentiation.
