Research Article

Dupilumab: Direct Cost and Clinical Evaluation in Patients with Atopic Dermatitis

Table 2

Median outcome and descriptive analysis of patients with moderate-to-severe atopic dermatitis.

Variables

Males, n (%)34/57 (59.7)
Median (IQR) age, years31 (24–47)

Treatment outcome
Median (IQR) annual expenditure/patient (euro)9073 (3661–14600)
Median (IQR) drug dispensing number22 (8–34)
Median (IQR) EASI at baseline31 (25–40)
Median (IQR) EASI at the end of treatment5 (1–10)
Median (IQR) delta EASI (%)86.8 (75–96)
Median (IQR) DLQI at baseline10 (10–25)
Median (IQR) DLQI at the end of treatment3 (1–5)
Median (IQR) delta DLQI (%)80 (70–90)
Median (IQR) NRS at baseline10 (8–10)
Median (IQR) NRS at the end of treatment2 (1–3)
Median (IQR) delta NRS (%)80 (70–90)
Monotherapy, n (%)44/56 (78.6)

Comorbidities
None, n (%)17/57 (29.8)
Allergic asthma, n (%)31/57 (54.4)
Allergic rhinitis and/or conjunctivitis, n (%)15/57 (26.3)
Bacterial skin infections, n (%)4/57 (7.0)
Recurrent herpetic infections, n (%)2/57 (3.5)
Neuropsychiatric diseases, n (%)0/57 (0.0)

Affected areas
Face/neck, n (%)48/57 (84.2)
Body, n (%)3/57 (5.3)
Genitals, n (%)28/57 (49.1)
Hands, n (%)42/57 (73.7)

Previous treatment
Topical corticosteroids, n (%)52/57 (91.2)
Topical immunomodulators (e.g., tacrolimus, pimecrolimus), n (%)26/57 (45.6)
Systemic corticosteroids, n (%)26/57 (45.6)
Cyclosporine, n (%)25/57 (43.9)
Methotrexate, n (%)1/57 (1.8)
Azathioprine, n (%)0/57 (0.0)
NB-UVB phototherapy, n (%)1/57 (1.8)
UVA1 phototherapy, n (%)0/57 (0.09)
PUVA phototherapy, n (%)1/57 (1.8)