The Strategy of Combining Antidepressants in the Treatment of Major Depression: Clinical Experience in Spanish Outpatients

Table 1

General characteristics of the three databases.

	Mar	Diana	Medas
Period of study	November 97	Septembert 98	February 01
	February 98	January 99	July 01
Objective of the study	Assess efficacy, onset of effect, and tolerance to mirtazapine in the treatment of major depression	Assess the efficacy and tolerance to mirtazapine in sleep and anxiety in major depression	Evaluate the clinical evolution of depression and somatic symptoms during the first three months of treatment with mirtazapine
Number of psychiatrists	300	150	100
Sample size	1261	877	704