The Strategy of Combining Antidepressants in the Treatment of Major Depression: Clinical Experience in Spanish Outpatients

Table 4

Comparative study of patients on one AD versus patients on AD combination.

	One AD	AD combination	Statistical Significance 𝑃≤.05
Sample size	775	64
Age	51.2 ± 14.35	53.1 ± 12.06	𝑍=−1.2	𝑃=.072%
Sex			𝜒^2=0.91	𝑃=.34
Women	72.7%	69.6%
Men	27.3%	30.4%
Marital status
Unmarried	13.9%	8.6%	𝜒^2=3.58	𝑃=.058
Married	62.8%	77.1%
Separated	11.5%	5.7%
Widowed	11.8%	8.6%
Unknown		0.6%
Age of onset	39.8 ± 15.1	40.3 ± 14.8	𝑍=−0.59	𝑃=.86
Suicide attempts	10.7%	16.5%	𝜒^2=1.56	𝑃=.21
Number of suicides/patient	0.19	0.36
Previous depressive episodes			𝜒^2=0.85	𝑃=.35
No	36.4	42.0
Yes	63.6	58.0
Other previous psychiatric disorders	25.0%	20.3%
Unleashing factors	46.7%	56.5%
Duration of episode (%)
2 weeks	1.8	0.0	𝜒^2=16.0	𝐏=.𝟎𝟎𝟏
2 weeks-1 month	14.7	5.9
1–6 months	47.2	38.2
7–12 months	15.5	11.8
over 1 year	20.7	44.1
Hamilton Scale	21.69	21.69	𝑍=0.287	𝑃=.77
Level of Depression (%)
Mild	18.5	18.7	𝜒^2=3.6	𝑃=.165
Moderate	40.6	50.0
Severe	41.0	31.2