Depression Treatment with Duloxetine and Reduction of Inability to Work
Table 1
Baseline characteristics.
Variable
(%)
Mean (SD)
Age (years; )
46.4 (10.0)
Gender: female ()
2050 (72.6)
Currently unable to work a ()
1266 (44.8)
Duration of inability to work in the last 12 months (weeks; )
7.8 (13.5)
Age at onset of depression (years; )
37.2 (11.7)
Time since onset of depression (years; )
9.2 (9.4)
Any hospitalization during the last 12 months ()
316 (11.2)
Any suicide attempt during the last 12 months ()
74 (2.6)
Duloxetine starting dose ()
30 mg
2051 (72.6)
60 mg
756 (26.8)
Reason to start or change to duloxetine ()
Inadequate efficacy of pretreatment
1365 (48.3)
Initial treatment
1350 (47.8)
Patient decision
412 (14.6)
Inadequate tolerability of pretreatment
314 (11.1)
History of antidepressant therapy in the last week () yes
1611 (57.0)
No antidepressant therapy
1214 (43.0)
Single antidepressant treatment
1219 (43.2)
Most common (>2% of patients) single antidepressant therapies:
Tricyclic antidepressant
515 (18.2)
Selective serotonin reuptake inhibitor
410 (14.5)
Noradrenergic and specific serotonergic antidepressant
126 (4.5)
Selective serotonin and noradrenaline reuptake inhibitor
74 (2.6)
Multiple antidepressant treatment
392 (13.9)
Patients with overall pain VAS >30 mm
2185 (79.4)
Any permanent pain medication ()
769 (27.2)
Any on demand pain medication in the last 12 months ()
1744 (61.7)
Any concomitant somatic diseases ()
1813 (64.2)
Most common (>9% of patients) concomitant somatic diseases:b
Muscle and skeleton diseases
871 (30.8)
Hypertension
573 (20.3)
Allergies
306 (10.8)
Metabolic diseases
277 (9.8)
Gastrointestinal diseases
275 (9.7)
Neurologic diseases
261 (9.2)
: number of patients with available data; : number of patients in category; SD: standard deviation.
aAnswer “yes” to the question “Is the patient unable to work today?”.
bAs selected from the check list.
