Increased risk of switch No increased risk of switch Study No. of participants Drug Comments Study No. of participants Drug Comments Antidepressants as Monotherapy Amsterdam and Shults 2005 [13 ] 34 (
,
) Fluoxetine, olanzapine/fluoxetine combination No Placebo Control Parker et al. 2006 [16 ] 10 BPII Escitalopram Small sample size Agosti and Stewart 2007 [21 ] 70 BP II Imipramine, phenelzine No valid tool used to assess switch Amsterdam and Shults 2008 [17 ] 83 BPII Venlafaxine Compared to Lithium, no placebo control McElroy et al. 2010 (EMBOLDEN II) [14 ] 740 (
,
) paroxetine Amsterdam and Shults 2010 [15 ] 148 BPII Fluoxetine No placebo control, subsyndromal hypomania in 19.6% Antidepressants with mood stabilizers Post et al. 2006 [40 ] 174 Venlafaxine 15%; no placebo control Schaffer et al. 2006 [27 ] 20 Citalopram Small sample size, no placebo control Truman et al. 2007 [30 ] 366 (
,
) Paroxetine, bupropion By self-report only Fonseca et al. 2006 [28 ] 20 Escitalopram Small sample size, no placebo control Amsterdam and Shults 2010 [15 ] 148 BPII Fluoxetine No placebo control, subsyndromal hypomania in 19.6% Sachs et al. 2007 [29 ] 366 (
,
) Paroxetine, bupropion Perlis et al. 2010 [45 ] 410 Olanzapine/fluoxetine combination, lamotrigine Conducted by Lilly Research Laboratories Sidor et al. 2011 [32 ] 1,034 (Meta- Analysis) Fluoxetine, paroxetine, bupropion, imipramine
