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Depression Research and Treatment
Volume 2014, Article ID 816524, 9 pages
Research Article

Personality Pathology Predicts Outcomes in a Treatment-Seeking Sample with Bipolar I Disorder

Alpert Medical School of Brown University and Butler Hospital, Psychosocial Research, 345 Blackstone Boulevard, Providence, RI, 02906, USA

Received 23 July 2013; Revised 1 October 2013; Accepted 8 October 2013; Published 2 January 2014

Academic Editor: H. Grunze

Copyright © 2014 Susan J. Wenze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We conducted a secondary analysis of data from a clinical trial to explore the relationship between degree of personality disorder (PD) pathology (i.e., number of subthreshold and threshold PD symptoms) and mood and functioning outcomes in Bipolar I Disorder (BD-I). Ninety-two participants completed baseline mood and functioning assessments and then underwent 4 months of treatment for an index manic, mixed, or depressed phase acute episode. Additional assessments occurred over a 28-month follow-up period. PD pathology did not predict psychosocial functioning or manic symptoms at 4 or 28 months. However, it did predict depressive symptoms at both timepoints, as well as percent time symptomatic. Clusters A and C pathology were most strongly associated with depression. Our findings fit with the literature highlighting the negative repercussions of PD pathology on a range of outcomes in mood disorders. This study builds upon previous research, which has largely focused on major depression and which has primarily taken a categorical approach to examining PD pathology in BD.