A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C

Table 2

Comparison of 5HT uptake rate (SUR) in healthy control subjects and patients with chronic HCV.

	𝑁	Mean (SD)	95% CI (mean)	𝑡-test versus control group	Effect size (𝑑)	95% CI (𝑑)
Control group	65	57.3 ( 9.4)	54.9–59.6
Patients total	65	64.8 (15.5)	61.0–68.7	𝑡105.5=3.345, 𝑃=0.001	0.585	0.23–0.93
Patients (BDI≤10)	49	62.5 (14.6)	58.5–66.9	𝑡77.34=2.272, 𝑃=0.026	0.437	0.061–0.812
Patients (BDI>10)	16	71.3 (17.0)	62.2–80.4	𝑡17.32=3.172, 𝑃=0.005	1.245	0.665–1.825
Patients with major/minor depression	12	80.1 (16.9)	63.3–90.8	𝑡12.3=4.545, 𝑃=0.001	2.105	1.40–2.80

Note: the standardized mean-difference effect size (𝑑) was computed from means and standard deviations; SUR is expressed in pMol/10⁹ plts. × 5 min.