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Depression Research and Treatment
Volume 2018, Article ID 5304759, 8 pages
Research Article

S100B Levels in Patients with Type 2 Diabetes Mellitus and Co-Occurring Depressive Symptoms

1Diabetes Center, First Department of Propaedeutic and Internal Medicine, Laiko General Hospital, National and Kapodistrian University, Medical School, Athens, Greece
2Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University, Medical School, Athens, Greece
3Heart Failure Unit, Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens, 1 Rimini St, 12462, Athens, Greece
4Department of Endocrinology, Nikaia General Hospital, Greece
5Mental Health Center, G. Gennimatas General Hospital, Athens, Greece
6First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Vassilissis Sofias Ave 72-74, 11528, Athens, Greece

Correspondence should be addressed to Panagiota Katsanou; rg.oohay@uonastakp

Received 28 April 2018; Revised 4 October 2018; Accepted 19 October 2018; Published 18 November 2018

Academic Editor: Janusz K. Rybakowski

Copyright © 2018 Panagiota Katsanou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Depression is a comorbid condition in patients with Type 2 Diabetes mellitus (T2DM). S100B, a glia derived protein, is linked to depression and has been suggested as a biomarker for depression outcomes in several populations. However, to date there is no data about S100B levels and depression in patients with T2DM. Objective. We hypothesized that S100B serum levels are increased in patients with T2DM and recently diagnosed, drug-free depressive symptoms, and could be used for the diagnosis of depression in T2DM. Methods. Overall 52 patients (62 ± 12 years, female 66, 7%) with no history of depression deriving from the Diabetes out-patient clinic of our University Hospital underwent a one-to-one interview with a psychiatrist and filled a self-assessment (Zung) questionnaire. Serum S00B levels were compared between 30 (63±12 years, female 66, 7%) diabetic patients without depressive symptoms vs 22 patients (62 ±12 years, female 68, 2%) with T2DM and depressive symptoms. Results. There was no difference in serum levels of S100B between patients with T2DM without depressive symptoms vs diabetic patients suffering from depressive symptoms (2.1 (1.9-10.9) pg/ml vs 2.4 (1.9-14.8) pg/ml, p=0. 637+). Moreover, linear regression analysis did not show any association between lnS100B levels and depressive symptoms (β = 0.084, 95% CI 0.470-0.871, and p=0.552), Zung self-assessment score (β = 0.048, 95% CI -0.024-0.033, and p=0.738), and other patients’ characteristics. Conclusions. In patients with T2DM there is no correlation between S100B serum levels and newly detected mild depressive symptoms. The brain biochemistry pathways of depression in T2DM warrant further investigation in a larger scale population.