Research Article
Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study
Table 4
Statistically significant correlations between MetaCyc pathway abundances and the Hamilton Depression Rating Scale scores at the end-CRT samples.
| MetaCyc pathway | End-CRT | Rho | value |
| Acetyl-CoA fermentation to butanoate II | -0.37 | 0.02 | Chondroitin sulfate degradation I (bacterial) | -0.33 | 0.04 | CMP-legionaminate biosynthesis I | -0.41 | 0.009 | Flavin biosynthesis I (bacteria and plants) | -0.36 | 0.02 | Inosine-5-phosphate biosynthesis III | 0.33 | 0.04 | GDP-mannose biosynthesis | -0.33 | 0.04 | L-methionine biosynthesis I | 0.36 | 0.02 | L-methionine biosynthesis III | 0.42 | 0.007 | Mono-trans, poly-cis decaprenyl phosphate biosynthesis | 0.36 | 0.02 | Myo-, chiro-, and scyllo-inositol degradation | -0.39 | 0.01 | Phosphopantothenate biosynthesis I | -0.39 | 0.02 | Superpathway of coenzyme A biosynthesis I (bacteria) | -0.42 | 0.007 | Superpathway of L-alanine biosynthesis | 0.36 | 0.02 | Superpathway of S-adenosyl-L-methionine biosynthesis | 0.33 | 0.04 |
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CRT = chemotherapy and radiation therapy.
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