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Evidence-Based Complementary and Alternative Medicine
Volume 3 (2006), Issue 4, Pages 447-457
http://dx.doi.org/10.1093/ecam/nel075
Review

DNA Microarrays in Herbal Drug Research

Bioprospecting Laboratory, Interdisciplinary School of Health Sciences, University of Pune, Pune 411007, India

Received 24 January 2006; Accepted 19 September 2006

Copyright © 2006 Preeti Chavan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.