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Evidence-Based Complementary and Alternative Medicine
Volume 3 (2006), Issue 4, Pages 541-545
http://dx.doi.org/10.1093/ecam/nel073
Original Article

Improvement of Memory by Means of Ultra-Low Doses of Antibodies to S-100B Antigen

Institute of Molecular Biology and Biophysics, Siberian Department of Russian Academy of Medical Sciences, Novosibirsk, Russia

Received 7 September 2005; Accepted 14 September 2006

Copyright © 2006 O. I. Epstein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antigen S-100B of nervous tissue, according to the data of numerous studies, affects the mechanisms of nervous system plasticity and memory. The influence of ultralow doses of antibodies to S-100B (6C dilution, according to the homeopathic pharmacopoeia) has been studied on three learning behavioral models on Wistar rats, which were inhibitory avoidance, choosing of bowls with sucrose and feeding behavior cessation after auditory signal. For all three tasks, parameters of reproduction of the learned skills improved after per oral administration of potentiated antibodies to S-100B antigen immediately after learning. Possible mechanisms of the anti-S-100B antibodies influence on memory formation are discussed.