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Evidence-Based Complementary and Alternative Medicine
Volume 4, Issue 1, Pages 59-63
Original Article

Recovery of Small-Sized Blood Vessels in Ischemic Bone under Static Magnetic Field

1International Innovation Center, Kyoto University, Kyoto, Japan
2Department of Sciences, Pip Tokyo Co. Ltd, Tokyo, Japan
3Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
4Faculty of Medical Engineering, Suzuka University of Medical Science, Mie, Japan

Received 19 October 2005; Accepted 5 July 2006

Copyright © 2007 Shenzhi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Effects of static magnetic field (SMF) on the vascularization in bone were evaluated using an ischemic bone model, where rat femoral artery was ligated. Magnetized and unmagnetized samarium–cobalt rods were implanted transcortically into the middle diaphysis of the ischemic femurs. Collateral circulation was evaluated by injection of microspheres into the abdominal aorta at the third week after ligation. It was found that the bone implanted with a magnetized rod showed a larger amount of trapped microspheres than that with an unmagnetized rod at the proximal and the distal region (P < 0.05 proximal region). There were no significant differences at the middle and the distal region. This tendency was similar to that of the bone mineral density in the SMF-exposed ischemic bone.