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Evidence-Based Complementary and Alternative Medicine
Volume 4 (2007), Issue 2, Pages 203-207
http://dx.doi.org/10.1093/ecam/nel088
Original Article

Nourishing Yin and Promoting Blood Circulation of TCM to Treat Hemorheologic Disorder Induced by Diabetes Mellitus in Rats

1Department of Basic Medicine, Zhejiang Chinese Medical University Binjiang, Hangzhou 310053, Zhejiang Province, China
2Department of Endocrinology, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China
3Department of Laboratory, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China

Received 1 February 2006; Accepted 12 October 2006

Copyright © 2007 Rong Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes mellitus, DM, is commonly accompanied with various stages of hemorheologic disturbances that are the main causes of the development of chronic DM. In this study, simple Chinese material medica [yang-yin jiang-tang preparation (YYJT)] was given to alloxan-induced DM rats and analyzed to compare the changes of fasting blood glucose (FBG), fasting insulin (FINS), hemorheologic parameters and insulin-like growth factor II (IGF-II) before and after administration. The results suggested that YYJT can significantly downregulate FBG (P < 0.005), improve insulin resistance and beta-cell secretion (P < 0.05), decrease whole blood viscosity at low and high shear rates, gathering of blood index test (GIT) and fibrinogen (FIB) (P < 0.05), and enlarge the function of IGF-II (P < 0.05). We concluded that YYJT could prevent and treat hemorheologic disorder in DM rats by means of reducing glucose, improving insulin resistance and elevating IGF-II.