Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2008 / Article

Original Article | Open Access

Volume 5 |Article ID 403632 | https://doi.org/10.1093/ecam/nem014

Sang Chan Kim, Sook Jahr Park, Jong Rok Lee, Jung Cheol Seo, Chae Ha Yang, Sung Hui Byun, "Cytoprotective Activity of Glycyrrhizae radix Extract against Arsenite-Induced Cytotoxicity", Evidence-Based Complementary and Alternative Medicine, vol. 5, Article ID 403632, 7 pages, 2008. https://doi.org/10.1093/ecam/nem014

Cytoprotective Activity of Glycyrrhizae radix Extract against Arsenite-Induced Cytotoxicity

Received09 May 2006
Accepted16 Jan 2007


Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated the effect of licorice on arsenite (As)-induced cytotoxicity in H4IIE cells, a rat hepatocyte-derived cell line. Cell viability was significantly diminished in As-treated H4IIE cells in a time and concentration-dependent manner. Furthermore, results from flow cytometric assay and DNA laddering in H4IIE cells showed that As treatment induced apoptotic cell death by activating caspase-3. Licorice (0.1 and 1.0 mg ml−1) treatment significantly inhibited cell death and the activity of caspase-3 in response to As exposure. These results demonstrate that licorice induced a cytoprotective effect against As-induced cell death by inhibition of caspase-3.

Copyright © 2008 Sang Chan Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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