Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2008 / Article

Original Article | Open Access

Volume 5 |Article ID 417350 | https://doi.org/10.1093/ecam/nem017

M. Rabbani, S. E. Sajjadi, A. Mohammadi, "Evaluation of the Anxiolytic Effect of Nepeta persica Boiss. in Mice", Evidence-Based Complementary and Alternative Medicine, vol. 5, Article ID 417350, 6 pages, 2008. https://doi.org/10.1093/ecam/nem017

Evaluation of the Anxiolytic Effect of Nepeta persica Boiss. in Mice

Received15 Jul 2006
Accepted16 Jan 2007


The aim of the present study was to evaluate the anxiolytic effects of hydroalcoholic extract (HE) of Nepeta persica Boiss. (Lamiaceae) on the elevated plus-maze (EPM) model of anxiety. The extract of arial parts of the plant was administered intraperitoneally to male NMRI mice, at various doses, 30 min before behavioural evaluation. The HE extract of N. persica at the dose of 50 mg kg−1 significantly increased the percentage of time spent and percentage of arm entries in the open arms of the EPM. This dose of plant extract affected neither animal's locomotor activity nor ketamine-induced sleeping time. The 50 mg kg−1 dose of the plant extract seemed to be the optimal dose in producing the anxiolytic effects, lower or higher doses of the plant produce either sedative or stimulant effects. At 100 mg kg−1, the plant extract increased the locomotor activity. These results suggested that the extract of N. persica at dose of 50 mg kg−1 possess anxiolytic effect with less sedative and hypnotic effects than that of diazepam and causes a non-specific stimulation at 100 mg kg−1.

Copyright © 2008 M. Rabbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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