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Evidence-Based Complementary and Alternative Medicine
Volume 6 (2009), Issue 2, Pages 159-164

Humor and Laughter May Influence Health IV. Humor and Immune Function

1Western Kentucky University, School of Nursing, AC Room 113D, 1906 College Heights Blvd # 11036, Bowling Green, KY 42101-1036, USA
2University of South Florida, USA

Received 25 July 2007; Accepted 26 July 2007

Copyright © 2009 Mary Payne Bennett and Cecile Lengacher. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This is the final article in a four part series reviewing the influence of humor and laughter on physiological and psychological well-being. This final article reviews the evidence for the effect of sense of humor, exposure to a humor stimulus and laughter on various immune system components, with a focus on the effects of laughter on natural killer cell cytotoxicity.